Synthesis and antiproliferative activity of peracetylated 2-amino-1,2-dideoxy-1-nitro-d-glycero-l-manno and d-glycero-d-talo heptitols

Synthesis and antiproliferative activity of sulfa-Michael adducts and thiochromenes derived from carbohydrates

“…It has been also found that antiproliferative activity of new thiochromenes is lower than that of starting nitroalkenes, according to the results previously reported for chromenes and 1,2dihydroquinolines, 25 and carbohydrate-derived aminoadducts. 20…”

“…Such evaluation was accomplished following the protocol of the National Cancer Institute (NCI) of the United States 29. Compounds 1 and 15 have been included with comparative purposes 20. Data are depicted inTable 1, and are expressed in GI50, that is, the concentration of the compound that inhibits 50% of the tumor cell growth.…”

Synthesis and antiproliferative activity of new 2-glyco-3-nitro-2H-chromenes

“…Based on the quantitative structure-activity relationship studies carried out by González-Díaz et al [23], from which it is concluded that more than 50% of the biological activity of the evaluated compounds lies in the trans-nitroolefin system, and confirmed by Steinfelder et al [13] and our own group [21,22,24], structures of 3-nitro-2H-chromenes at positions 2, 6 and 8 were modified to evaluate how it affected the antiproliferative activity.…”