Synthesis and Antioxidant Activity of Tricyclic Compounds Containing a 5,6,7,8-Tetrahydroquinoline Moiety

Pharmacoprophylaxis of liver diseases: creating a new hepatoprotector

“…As the study of pharmaco-toxicological properties of the heterocyclic pyrido [4,3,2-de] cinnoline parameters were analyzed determining the level of lipid peroxidation (LPO) (malondialdehyde (MDA), diene conjugates (DC)) and the activity of key antioxidant enzymes (superoxide dismutase (SOD), catalase) [7].…”

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The article presents a study of the hepatoprotective activity of a tricyclic heterocycle, which refers to 5,6,7,3, cinnolin-3 (7H) was studied on rats under the influence of the model of toxic hepatosis induced by carbon tetrachloride to find out the indicators of peroxidation and biochemical indicators. Biochemical studies have shown that modelling toxic fat hepatosis caused by the inception of carbon tetrachloride to rats increased the activity of alanine aminotransferase by 2.5 times more compared with the intact group, indicating the development of oxidative stress induced by the treatment of pyrido [4,3,2] Cinnol I that reduced the toxic effect of CTC by 79.9 %.

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Design, synthesis, and antitumor evaluation of novel methylene moiety-tetheredtetrahydroquinoline derivatives

“…2,6-Bis(morpholinomethyl)cyclohexanonedihydrochloride (7) was obtained from the reaction of cyclohexanone, paraformaldehyde, and morpholine hydrochloride according to the literature [1]. Pale yellow solid; yield: 57%; mp 163-164°C.…”

“…In this regard, the synthesis of new organic molecules for bioactivity evaluation or modification studies on molecules creates a wide working area for synthetic chemists. In recent years, tetrahydroquinolines (THQs) have been considered to be one of the pharmaceutical agents that have the greatest interest in the chemistry of quinolines due to their broad biological and pharmacological activities [4][5][6][7]. The most potent effects among a variety of pharmacological activities are exhibited by 1,2,3,4-THQs [8][9][10][11][12], such as glucocorticoid receptor agonists [13], antagonists of vasopressin V 2 receptor [14], and antitumor agents targeting the colchicine site on tubulin [15].…”

“…A second type of THQ with the 5,6,7,8-THQ structure has appeared in some reports in which their potential biopharmaceutical effects were evaluated [16][17][18]. Recently, 5,6,7, derivatives have been presented to act as anti-HIV-1 agents [19], anticancer agents [20], and antagonists against metabotropic glutamate receptors (mGluRs) 1 (Figure 1), which play a crucial role in the prevention and control of acute neurological disorders [21]. A recently published study illustrated that a wide variety of 5,6,7,8-THQ derivatives have exhibited remarkable cytotoxic activity against human colon carcinoma HT29, hepatocellular carcinoma HepG2, and Caucasian breast adenocarcinoma MCF-7 cells lines [22].…”