Synthesis and antioxidant activity of monoterpene nitrobenzylidenesulfenimines

Synthesis and Antioxidant Capacity of Some Derivatives of Sesamol at the C‐6 Position

“…MPA of these derivatives (after 5 h incubation) statistically significantly surpassed ( p =0.005, 0.005, 0.003, and 0.011, respectively) the activity of sesamol ( 1 ) and was comparable to the BHT activity. The effectiveness of trolox at the same concentration under conditions of H 2 O 2 ‐induced oxidative stress (decreased hemolysis) was lower than BHT and amounted to about 20 % [37] . Interestingly, methylenebisphenol 12 , which showed the highest AOA on the substrate obtained from brain of lab animals ( Table 1), in this experiment showed a high prooxidant activity, which follows from a sharp increase in the level of hemolysis compared to the control during the entire period of cell incubation ( Table S2 ( Supporting Information )).…”

“…To assess the antioxidant potential of the synthesized compounds 2 – 5 , 7a – 12 , we used an already established set of methods [13,15–21,36,37] . Sesamol ( 1 ) and the standard antioxidant BHT (2,6‐di‐ tert ‐butyl‐4‐methylphenol) [38,39] were taken as the most suitable reference compounds.…”

“…In this respect these compounds significantly surpassed sesamol ( 1 ) ( p =0.021) and were comparable in activity to BHT. Previously, it was shown that trolox, an analog of vitamin E, at the same concentration had an extremely weak inhibitory effect on brain lipid peroxidation (LPO) despite the high RSA in the DPPH‐test [19,20,37] . In order to identify the most effective compound, we studied this group of derivatives at a concentration of 1 μM: the highest activity was observed in prenylsesamol ( 10 ) and methylenebisphenol 12 , which, along with compound 11 , were significantly more active than BHT ( p =0.021).…”

Ceylon cinnamon and clove essential oils as promising free radical scavengers for skin care products

“…In addition to endogenous sources, more and more free radicals come from exogenous sources (excessive exposure to UVA rays and other radiation, air pollution, cigarette smoke, etc.). The imbalance between production and accumulation of free radicals causes oxidative stress in human body, including the skin (Poljšak and Dahmane, 2012;Pizzino et al, 2017;Sudarikov et al, 2021). To either prevent these reactive species from formation or remove them before they can damage vital components of the skin cells, synthetic antioxidants such as α-tocopherol, butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) are commonly incorporated into skin care products (Hatwalne, 2012;Ácsová et al, 2021).…”

Thioterpenoids as Potential Antithrombotic Drugs: Molecular Docking, Antiaggregant, Anticoagulant and Antioxidant Activities

“…Sulfides 1 and 4 were close to the previously studied (−)-cis-verbenol in terms of their ability to inhibit the accumulation of LPO secondary products (TBA-RS) and surpassed most of the other studied bicyclic monoterpene alcohols ((−)-neoisoverbanol, (+)-3α, 4α-carandiol, (−)-3β, 4α-carandiol, (+)-3β, 4β-carandiol, (−)-2α, 3α-pinandiol, (−)-2α, 3β-pinandiol, (−)-3α, 4β-pinandiol, pinocampheol, (±)-2-exo-10-endo-camphandiol, (−)-isocaranol-4, (−)-cis-myrtanol, (−)-trans-myrtanol, (−)-myrtenol) [ 28 ]. However, sulfides 1 and 4 at a concentration of 1 mM were less active than trolox, an analogue of vitamin E [ 29 , 30 ]. For sulfoxides 2 and 5 , as well as for sulfones 3 and 6 , no antioxidant activity was detected in this model system.…”