Synthesis and antimycobacterial activity of (3,4-diaryl-3H-thiazol-2-ylidene)-hydrazide derivatives

Mamolo, Maria Grazia; Falagiani, Valeria; Zampieri, Daniele; Vio, Luciano; Banfi, Elena; Scialino, Giuditta

doi:10.1016/s0014-827x(03)00103-4

Cited by 50 publications

(28 citation statements)

References 6 publications

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“…-2-yl)-1,3,4-thidiazole-2-yl]acetic acid (3,4-diaryl-3H-thiazole-2-ylidene)hydrazide derivatives 42 were synthesized and tested for their in vitro antimycobacterial activity towards three strains. Compound 42s was exhibited at 20 μg/mL against M.tuberculosis 190, isolated from bronchial aspirates [49]. …”

Section: Antimycobacterial Activitymentioning

confidence: 99%

Biological Activities of Hydrazone Derivatives

2007

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There has been considerable interest in the development of novel compounds with anticonvulsant, antidepressant, analgesic, antiinflammatory, antiplatelet, antimalarial, antimicrobial, antimycobacterial, antitumoral, vasodilator, antiviral and antischistosomiasis activities. Hydrazones possessing an azometine -NHN=CH-proton constitute an important class of compounds for new drug development. Therefore, many researchers have synthesized these compounds as target structures and evaluated their biological activities. These observations have been guiding for the development of new hydrazones that possess varied biological activities.

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Section: Antimycobacterial Activitymentioning

confidence: 99%

Biological Activities of Hydrazone Derivatives

2007

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“…Thiazole derivatives have well established with antituberculosis effects in many studies [25][26][27][28][29][30] . Studies combined these two rings, thiazole and isatin have also been reported 31,32 .…”

Section: Introductionmentioning

confidence: 99%

Synthesis and antimycobacterial activity evaluation of isatin-derived 3- [(4- aryl - 2- thiazolyl])hydrazone]-1h- indol- 2, 3- diones

Yurttaş¹,

Ertaş²,

Cankılıç³

et al. 2017

actapharm

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“…For these reasons we have introduced hydrazide and 1,3,4-oxadiazole moieties to the pyridazine ring to enhance the cytotoxic activity. Hydrazides are very useful starting materials for the construction of several heterocyclic compounds such as 1,3,4-oxadiazoles [13], 1,3-thiazoles [14], 1,3,4-thiadiazoles [15], 1,2,4-triazoles [16] [18], pyrroles [19] and pyrazoles [20]. The common practical route for hydrazide synthesis is the treatment of esters with hydrazine hydrate.…”

Section: Introductionmentioning

confidence: 99%

Utilization of Cyanoacetohydrazide and Oxadiazolyl Acetonitrile in the Synthesis of Some New Cytotoxic Heterocyclic Compounds

Shaker

Marzouk

2016

Molecules

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A (pyridazinyl)acetate derivative was reacted with thiosemicarbazide and hydrazine hydrate to yield spiropyridazinone and acetohydrazide derivatives, respectively. The acetohydrazide derivative was used as a starting material for synthesizing some new heterocyclic compounds such as oxoindolinylidene, dimethylpyrazolyl, methylpyrazolyl, oxopyrazolyl, cyanoacetylacetohydrazide and oxadiazolylacetonitrile derivatives. The behavior of the cyanoacetylacetohydrazide and oxadiazolylacetonitrile derivatives towards nitrogen and carbon nucleophiles was investigated. The assigned structures of the prepared compounds were elucidated by spectral methods (IR, 1 H-NMR 13 C-NMR and mass spectroscopy). Some of the newly prepared compounds were tested in vitro against a panel of four human tumor cell lines, namely hepatocellular carcinoma (liver) HePG-2, colon cancer HCT-116, human prostate cancer PC3, and mammary gland breast MCF-7. Also they were tested as antioxidants. Almost all of the tested compounds showed satisfactory activity.

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Synthesis and antimycobacterial activity of (3,4-diaryl-3H-thiazol-2-ylidene)-hydrazide derivatives

Cited by 50 publications

References 6 publications

Biological Activities of Hydrazone Derivatives

Biological Activities of Hydrazone Derivatives

Synthesis and antimycobacterial activity evaluation of isatin-derived 3- [(4- aryl - 2- thiazolyl])hydrazone]-1h- indol- 2, 3- diones

Utilization of Cyanoacetohydrazide and Oxadiazolyl Acetonitrile in the Synthesis of Some New Cytotoxic Heterocyclic Compounds

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