Synthesis and antimycobacterial activity of 3,5-disubstituted thiadiazine thiones

Tricarbonylrhenium(I) Complexes with N‐Heterocyclic Thiones and Selenols

“…The versatility of such ligands together with their varying coordination modes makes them interesting for a number of models in bioinorganic chemistry. [6][7][8] Recently, they have also been considered for potential radiopharmaceutical applications as tricarbonyl rhenium and technetium compounds. They have been included as coordination sites of pincer-type chelators [9,10] or used as components for so-called [2+1] complexes.…”

Reactivity of [M4(co)12(µ-pyms)4] (M = Mn, re; pymS = pyrimidine-2-Thiolate) with bis(triphenylphosphino)nickel(ii) dicarbonyl: X-ray crystal structure of [Re(Co)3(?2-pymS)(PPh3)]

“…Interest in the chemistry of transition metal complexes containing heterocyclicthiolate ligands stems from their structural diversity , Kitagawa et al 1990, Azam et al 2002, Kabir et al 1996, Brodie et al 1986, biological relevance (Canzoniero et al 2003, Hwu et al 2002, Katiyar et al 2003 and candidacy as precursors for metal-sulfide materials (Berardini et al 1995). Pyridine-2-thiol and pyrimidine-2-thiol are versatile ligands known to exhibit a variety of coordination geometries and mono-, di-and polynuclear metal complexes containing these ligand have been shown to display a range of different structural types .…”

Synthesis of partially hydrogenated 1,3,5-thiadiazines by Mannich reaction

“…The most studied derivatives of thiadiazine, 3,5-disubstituted tetrahydro-1,3,5-thiadiazine-2-thiones (THTTs) with general formula 1 (Fig. 1) have a wide range of applications, based on their antifibrinolytic, 1,2 antituberculosis, [3][4][5] fungicidal and bactericidal, 6 anthelmintic, 7 antitumor and anticancer, 8 hyperglycemic, 9 and other types of activity. Many THTTs are active antidermatophytes, 10 such as the antifungal drug sulbentine (dibenzthion) 2.…”

“…30 Despite the availability and diversity of condensed 1,3,5-thiadiazine derivatives, the potential applications of these compounds have been much less studied. We should note the fungicidal activity of pyrazolo [1,5-c] [1,3,5]thiadiazin-2-ones 11 (Fig. 3), 31 which also act as inhibitors of photosynthetic electron transport in photosystem II.…”

“…3), 31 which also act as inhibitors of photosynthetic electron transport in photosystem II. 32 It was recently discovered that pyrido [2,1-b] [1,3,5]thiadiazine 12 is an effective inhibitor of tick-borne flavivirus replication. 33 Among all possible strategies for building the 1,3,5-thiadiazine scaffold, we should emphasize the use of various Mannich type reactions -double aminomethylation of S,N-binucleophilic substrates (thioamides, dithiocarbamates, 2-mercaptoazoles and -azines, thiolactams, etc.…”