Synthesis and Antimicrobicidal Activity of Phenothiazinophanes: A New Class of Permanent Fluorescence Sensing Stilbenophanes

Kanagalatha, Rajagopal; Rajakumar, Perumal; Selvi, Canan; Mohan, N R

doi:10.14233/ajchem.2015.19128

Cited by 2 publications

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“…The stilbenophane 48d, with six phenothiazine units, was the best compound of the series, showing zone of inhibition diameters of 26.8 mm in S. pneumoniae (Gram-positive bacterium) and 23.4 mm in K. pneumoniae (Gram-negative bacterium) at the concentration of 50 µ g/mL. This finding suggested a positive correlation between the increasing number of phenothiazine units and the antimicrobial effect [87].…”

Section: Combretastatins and Their Analoguesmentioning

confidence: 86%

“…Recent studies have reported the preparation of cyclophanes constituted of phenothiazine units [84] with photoluminescence and electrochemical characteristics [85,86]. To obtain supramolecular systems with fluorescent sensing features useful in biology, Kanagalatha et al [87] synthesised new phenothiazine-based fluorescent stilbenophanes (47, 48a-d) and chiral phenothiazinophanes (49a-c) (Figure 12), and they tested them against a panel of bacteria (S. aureus, S. pneumoniae, E. coli, K. pneumonia, P. vulgaris, S. typhi, and S. flexner). The stilbenophane 48d, with six phenothiazine units, was the best compound of the series, showing zone of inhibition diameters of 26.8 mm in S. pneumoniae (Gram-positive bacterium) and 23.4 mm in K. pneumoniae (Gram-negative bacterium) at the concentration of 50 µ g/mL.…”

Section: Combretastatins and Their Analoguesmentioning

confidence: 99%

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Stilbenoids: A Natural Arsenal against Bacterial Pathogens

et al. 2020

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The escalating emergence of resistant bacterial strains is one of the most important threats to human health. With the increasing incidence of multi-drugs infections, there is an urgent need to restock our antibiotic arsenal. Natural products are an invaluable source of inspiration in drug design and development. One of the most widely distributed groups of natural products in the plant kingdom is represented by stilbenoids. Stilbenoids are synthesised by plants as means of protection against pathogens, whereby the potential antimicrobial activity of this class of natural compounds has attracted great interest in the last years. The purpose of this review is to provide an overview of recent achievements in the study of stilbenoids as antimicrobial agents, with particular emphasis on the sources, chemical structures, and the mechanism of action of the most promising natural compounds. Attention has been paid to the main structure modifications on the stilbenoid core that have expanded the antimicrobial activity with respect to the parent natural compounds, opening the possibility of their further development. The collected results highlight the therapeutic versatility of natural and synthetic resveratrol derivatives and provide a prospective insight into their potential development as antimicrobial agents.

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Section: Combretastatins and Their Analoguesmentioning

confidence: 86%

Section: Combretastatins and Their Analoguesmentioning

confidence: 99%

Stilbenoids: A Natural Arsenal against Bacterial Pathogens

et al. 2020

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“…More recently the known system 395.8 was explored as an antimicrobial agent, capable of inhibiting both bacterial and fungal pathogens ( Scheme 395 ). 776 In 2020, Jiang, Zhu, and co-workers reported the synthesis of phenoxathiin-based molecular belts. 777 The biphenolic building blocks 395.2 and 395.5 were obtained over a series of steps starting from 395.1a .…”

Section: Macrocyclic Systemsmentioning

confidence: 99%