Synthesis and Antimicrobial Study of New 8-bromo-1,3-diaryl-2,3-dihydro-1H-naphtho[1,2e][1,3]oxazines

Mayekar, Anil N.; Yathirajan, H. S.; Narayana, B.; Sarojini, B. K.; Kumari, N. Suchetha; Harrison, William T. A.

doi:10.5539/ijc.v3n1p74

Cited by 26 publications

(16 citation statements)

References 18 publications

(8 reference statements)

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“…Some fluorescent dyes such as Nile red and Nile blue possess the aromatic benzphenoxazine structural motif. 126 The 1,3-oxazines possess biological properties such as antifungal, 127,128 antibacterial, 129,130 antitumor, 131 antimalarial 132 and anti-HIV agents. 133 They are also used as monomers for polymer formation and photochromic agents.…”

Section: Synthesis Of Dihydroxazinesmentioning

confidence: 99%

Recent applications of aziridine ring expansion reactions in heterocyclic synthesis

Singh¹,

Sudheesh²,

Keroletswe³

2017

Arkivoc

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The inherent reactivity of the aziridine ring due to ring-strain makes it valuable building blocks for the synthesis of other heterocyclic motifs of biological relevance. Of particular significance is the generation of azomethine ylides from them and cycloaddition of ylides with alkenes, alkynes, and heterocumulenes. The ring undergoes opening followed by cyclization with a variety of reagents either in the presence of a catalyst or without any catalyst. This review article discusses the recent applications of aziridines in syntheses of four-to seven-membered heterocycles of biological relevance such as azetidines, 2

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Section: Synthesis Of Dihydroxazinesmentioning

confidence: 99%

Recent applications of aziridine ring expansion reactions in heterocyclic synthesis

Singh¹,

Sudheesh²,

Keroletswe³

2017

Arkivoc

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“…Compounds 3g , 3i , and 3j were previously synthesized using standard Betti method , the obtained results raising some doubts. The difference in melting points between our and literature data reaches in certain cases about 70°C, and 1 Н NMR studies exhibit the presence of only one tautomer, which is impossible for this sort of compounds.…”

Section: Resultsmentioning

confidence: 99%

“…; mp: 100°C, ref. ; mp: 150–152°C); 1 H NMR (CDCl 3 ): δ (tautomer A ) 6.41 (s, CHN), 8.63 (s, CH═N), (tautomer B ) 5.63, 5.72 (2s, CHN), (tautomer C ) 5.86, 5.94 (2s, CHN), (tautomers A + B + C ) 7.26–7.96 (m, CH arom ); IR (KBr): ν 1590, 1618 (С═С arom ), 3320 (NH). Anal .…”

Section: Methodsmentioning

confidence: 99%

Synthesis of 1‐(α‐Aminobenzyl)‐2‐naphthol Derivatives, their Structure in Crystal and in Solution

Metlushka

Sadkova

Shaimardanova

et al. 2014

Journal of Heterocyclic Chem

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“…They possess various biological activities such as antimicrobial [3], hypolipidacmic [4], antidiabetic [5], anti-inflammatory [6], antimycobacterial [7], antithrombotic [8], antagonism to progesterone receptor [9], antitumor [10], antiviral [11], leucocyte clastase [12] and scrotonin reuptakes [13]. The ground state equilibration of organic compounds was established using spectroscopic data [14].…”

Section: Intrductionmentioning

confidence: 99%

Hammett Spectral Correlations in some Aryl 1,3-Oxazine-4-Thione Derivatives

Thirunarayanan

Sekar

2014

ILCPA

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A series of some aryl 1,3-oxazine-4-thione derivatives have been synthesized by 1-methyl imidazole catalyzed three component one pot synthetic method in room temperature. The purities of these thiones were studied by their physical constants and spectroscopic data. The infrared and 13 C NMR spectral data of CN and CS were correlated with Hammett substituent constants, F and R parameters using single and multi-linear regression analysis. From the results of statistical analysis, the effect of substituent on the spectral data was studied.Keywords: 1,3-oxazine-4-thiones; IR spectra; 13 C NMR spectra; Hammett correlation INTRDUCTIONAryl 1,3-oxazine-4-thiones are pharmaceutical important heterocycles [1,2] [21]. The spatial arrangement of protons such as cis and trans of organic stereo chemical compounds [22] were studied using NMR spectra. Currently chemists and spectroscopic researchers [23][24][25][26][27][28][29] have paid much more interest for correlation of spectral data with Hammett substituent constants. Thirunarayanan and Ravi [30] have studied the effect of substituents of some pyrazoline-1-ethanones. Substituent effects on the spectral group frequencies of 9H-fluorenayl bromides were studied by Thirunarayanan [31]. Sakthinathan et al., have investigated the effect of substituents on naphthyl based pyrazoline derivatives [32]. Sasikala et al.,[22] have evaluated the effect of substituents and antimicrobial activities of some 5-bromo-2-thienyl based pyrazolines. The spectral correlation of infrared and nuclear magnetic resonance spectra of E-imines have been predicted by Sakthinathan et. al. and Suresh et al.,[33,34]. Thirunarayanan and Sekar have investigated the substituent effects on the IR and NMR spectral frequencies of some 3-(3,4-

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Synthesis and Antimicrobial Study of New 8-bromo-1,3-diaryl-2,3-dihydro-1H-naphtho[1,2e][1,3]oxazines

Cited by 26 publications

References 18 publications

Recent applications of aziridine ring expansion reactions in heterocyclic synthesis

Recent applications of aziridine ring expansion reactions in heterocyclic synthesis

Synthesis of 1‐(α‐Aminobenzyl)‐2‐naphthol Derivatives, their Structure in Crystal and in Solution

Hammett Spectral Correlations in some Aryl 1,3-Oxazine-4-Thione Derivatives

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