Synthesis and Antimicrobial Studies of New [Tetrakis (1, 2, 4-Triazole / 1, 3, 4-Oxadiazole / 1, 3, 4-Thiadiazole] [Bis-(Benzene-1, 3, 5-Triyl)] Dioxymethylene Compounds

Abstract

Synthesis of new heterocyclic compounds containing four five-membered rings together was the main goal of this work. The new derivatives of [tetrakis (1,2,4triazole /1,3,4-thiadiazole /1,3,4-oxadiazole][bis-(benzene-1,3,5-triyl)] dioxymethylene A7-A18 were synthesized by the reaction of [bis-(dimethyl 5-ylisophthalate)] dioxymethylene compound A1 which was previously prepared from the reaction of 1,2-dibromomethan and dimethyl 5-hydroxyisophthalate, then treated with hydrazine hydrate to yield the corresponding acid hydrazide A2. In the next step, compound A2 was refluxed with 4-substituted isothiocyanate to give substituted thiosemicarbazides A3-A6. The treatment of the latter compounds in basic medium of 2M of NaOH afforded 1,2,4-Triazole derivatives A7-A10. Whereas the reaction of the same compounds with concentrated sulfuric acid gave 1,3,4thiadiazoles A11-A14. Furthermore, the new derivatives of 1,3,4-oxadiazole A15-A18 were obtained by the reaction of thiosemicarbazides and tosyl chloride in presence of pyridine. (C. H. N.) elemental analysis, FT-IR, and 1 HNMR techniques were used to characterize the chemical structure of some of the new synthesized compounds which also exhibited an important biological activity.

Synthesis and Identification of New Azolidine-4-one Derived from Creatinine and Study their Anticancer and Antioxidant Effects

“…A solution of benzaldehyde, p-hydroxybenzaldehyde or p-aminoacetophenone (5 mmol) and hydrazide derivative 3 (5 mmol) was dissolved in ethanol absolute (20 mL), and a few drops of glacial acetic acid were added. The reaction mixture was then refluxed for 6 hours before cooling to room temperature, and the solid crude material was filtered and recrystallized from ethanol [14]. The physical properties of the title compounds 4-6 are listed in Table 1.…”

Synthesis and Characterization of some new heterocyclic derivatives from aromatic carbonyl ‎compounds and carboxylic acids with Evaluation some of them for biological activity

“…They are working continuous to bring chemical synthesis and environmental stewardship into harmony and to create a more environmentally conscious and sustainable drug development landscape [2][3][4][5]. The molecular structure of a compound profoundly influences its biological activity, and herein lies the allure of heterocyclic compounds, many of which feature the inclusion of sulfur [6][7] and nitrogen [8][9][10] atoms. Such compounds bear the potential to wield substantial pharmaceutical activity and manifest in diverse medical applications, thus underscoring their significance and multifaceted nature [11].…”

“…Extensive studies have elucidated the therapeutic effects of compounds harboring the 1,3,4-thiadiazole ring [12][13], shedding light on their prowess in combating a myriad of pathological states encompassing antibacterial, antimycotic, antitubercular, anti-Parkinson, cancer-fighting, anti-inflammatory, and anticonvulsant activities. [14][15][16][17][18]. The 1,2,4-triazole ring has been shown to have a wide range of pharmacological properties, including antibacterial and antifungal properties [19].…”