Synthesis and antimicrobial screening of N-(1-methyl-1H-pyrazole-4-carbonyl)-thiourea derivatives

Nițulescu, George Mihai; Drăghici, Constantin; Chifiriuc, Mariana Carmen; Măruţescu, Luminiţa; Bleoţu, Coralia; Missir, Alexandru Vasile

doi:10.1007/s00044-010-9541-9

Cited by 18 publications

(9 citation statements)

References 10 publications

(8 reference statements)

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“…[118] Limban and Missir prepared a series of thioureides of 2-(4-methyl/methoxy-phenoxymethyl)-benzoic acid with antimicrobial activity. [332][333][334][335] Similar antimicrobial activity against pathogenic bacteria and fungi were reported for chlorinated derivatives. [118] In similar fashion, thiourea derivatives bearing benzothiazole moiety possessed a broad spectrum of activity against microorganisms showing higher activity against fungi than bacteria.…”

Section: Biological Aspectssupporting

confidence: 54%

A review on the chemistry, coordination, structure and biological properties of 1-(acyl/aroyl)-3-(substituted) thioureas

Saeed

Flörke

Erben

2013

Journal of Sulfur Chemistry

194

123

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This review provides an overview of the chemistry, structure and potential applications of 1-(acyl/aroyl)-3-(mono-substituted) and 1-(acyl/aroyl)-3,3-(di-substituted) thioureas, with general formula R 1 C(O)N (1) HC(S)N (3) R 2 R 3 . In recent years, the title compounds have found extensive applications as ligands in coordination chemistry. The effect that nitrogen substituents exert on the intra-and intermolecular hydrogen-bonding interactions is discussed, including their role on the coordination properties displayed by these ligands. Novel applications of transition metal complexes bearing 1-(acyl/aroyl)-3-(mono-and di-substituted) thioureas are introduced. Biological aspects are also highlighted. As recently demonstrated, high-throughput screening assay and structure-activity analyses are feasible for this class of compounds. The chemical versatility of 1-(acyl)-3-(substituted) thiourea molecules and the derived metal complexes, together with the possibility of determining detailed structural properties, join biological applications in a promising interdisciplinary approach. The bibliography includes 382 references with emphasis on the literature appearing after 2007.

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Section: Biological Aspectssupporting

confidence: 54%

A review on the chemistry, coordination, structure and biological properties of 1-(acyl/aroyl)-3-(substituted) thioureas

Saeed

Flörke

Erben

2013

Journal of Sulfur Chemistry

194

123

View full text Add to dashboard Cite

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“…A series of N -(1-methyl-1 H -pyrazole-4-carbonyl)-thiourea derivatives were prepared and evaluated for antibacterial and antifungal activities. Compound 209 was found to be the most potent antimicrobial agent [ 113 ]. The synthesis and antibacterial activity of pyrazole derivative were described by Tanitame et al Results showed that the compound 210 possesses potent antibacterial activity and selective inhibitory activity against bacterial topoisomerases ( MRSA , PRSA and VRE ) with MIC = 1–2 µg/mL [ 114 ].…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

Synthesis and Pharmacological Activities of Pyrazole Derivatives: A Review

et al. 2018

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Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. The presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antipsychotic CDPPB, the anti-obesity drug rimonabant, difenamizole, an analgesic, betazole, a H2-receptor agonist and the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. Owing to this diversity in the biological field, this nucleus has attracted the attention of many researchers to study its skeleton chemically and biologically. This review highlights the different synthesis methods and the pharmacological properties of pyrazole derivatives. Studies on the synthesis and biological activity of pyrazole derivatives developed by many scientists around the globe are reported.

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“…Thioureas are important organic compounds possessing significant biological activities, act as corrosion inhibitors, catalyst and antioxidant, and are polymer components [1][2][3][4][5][6][7][8][9][10][11][12][13]. Moreover, the hydrogen-bonding ability of the thiourea moiety has been extensively used in the construction of anion receptors.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and crystal structure of cis-bis[4-fluoro-N-(diethylcarbamothioyl)benzamido-κ2O,S]platinum(II)

et al. 2015

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Synthesis and antimicrobial screening of N-(1-methyl-1H-pyrazole-4-carbonyl)-thiourea derivatives

Cited by 18 publications

References 10 publications

A review on the chemistry, coordination, structure and biological properties of 1-(acyl/aroyl)-3-(substituted) thioureas

A review on the chemistry, coordination, structure and biological properties of 1-(acyl/aroyl)-3-(substituted) thioureas

Synthesis and Pharmacological Activities of Pyrazole Derivatives: A Review

Synthesis, characterization and crystal structure of cis-bis[4-fluoro-N-(diethylcarbamothioyl)benzamido-κ2O,S]platinum(II)

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