Synthesis and antimicrobial properties of Zn-mineralized alginate nanocomposites

Malagurski, Ivana; Lević, Steva; Pantić, Milena; Matijašević, Danka; Mitrić, Miodrag; Pavlović, Vladimir; Dimitrijević-Branković, Suzana

doi:10.1016/j.carbpol.2017.02.064

Cited by 44 publications

(16 citation statements)

References 38 publications

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“…This value is in accordance with literature data reported for Zn-alginate microbeads with significantly higher alginate concentration (i.e. 1.9 % w/w vs. 0.5 % w/w in the present work) in which the total Zn 2+ content was determined as 159 ± 7 µmol/g [39]. The obtained results imply that AC did not interfere with Zn 2+ .…”

Section: Discussionsupporting

confidence: 93%

Novel composite zinc-alginate hydrogels with activated charcoal aimed for potential applications in multifunctional primary wound dressings

Osmokrović¹,

Jančić²,

Janković-Čaštvan³

et al. 2019

Hem Ind

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Composites based on Zn-alginate hydrogels in the form of beads were produced by extrusion of a suspension containing 0.5 % w/w of alginate and 20 % w/w of activated charcoal (AC) with the intent to simultaneously release two active agents, Zn 2+ and AC particles, in a physiological-like environment. The obtained composite beads were analyzed by FE-SEM and characterized regarding textural parameters, as well as Zn 2+ and AC release kinetics in the physiological saline solution. Zn 2+ ions were quickly released reaching the equilibrium concentration within the first hour in the contrary to the release of AC particles, which was described by internal diffusion with the apparent diffusion coefficient of approximately 10-13 m 2 s-1. Potential functionality of the obtained beads was evaluated regarding antibacterial activity in suspensions of the standard bacterial strain Escherichia coli 25922. The observed strong bactericidal effects were related to the quick release of Zn 2+ that was not affected by AC. Thus, taking into account results of this study, as well as high sorption capacity of alginate hydrogel, efficiency of AC to adsorb malodor and tissue degradation products and positive effects of Zn 2+ on wound healing, the obtained composites have shown promising potentials for applications as multifunctional wound dressings.

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Section: Discussionsupporting

confidence: 93%

Novel composite zinc-alginate hydrogels with activated charcoal aimed for potential applications in multifunctional primary wound dressings

Osmokrović¹,

Jančić²,

Janković-Čaštvan³

et al. 2019

Hem Ind

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“…Calcium alginate exhibits negligible antibacterial and cytotoxic activity[5]. However, zinc alginates have shown strong antibacterial activity against a wide range of microorganisms [6–9] due to its inhibition of conserved metabolic pathways involved in synthesis of essential biomolecules or antioxidant depletion[10], and it is well-known that Zn 2+ may produce toxic effects in human cells [11]. Alternative materials such as graphene oxide (GO), which from the graphene family shows the easiest processing, larger scale production and less expensive cost [12], has recently exhibited antibacterial capacity and negligible mammalian cytotoxicity in calcium alginate [5].…”

Section: Introductionmentioning

confidence: 99%

Graphene oxide in zinc alginate films: Antibacterial activity, cytotoxicity, zinc release, water sorption/diffusion, wettability and opacity

et al. 2019

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Alginate is considered an exceptional biomaterial due to its hydrophilicity, biocompatibility, biodegradability, nontoxicity and low-cost in comparison with other biopolymers. We have recently demonstrated that the incorporation of 1% graphene oxide (GO) into alginate films crosslinked with Ca 2+ cations provides antibacterial activity against Staphylococcus aureus and methicillin-resistant Staphylococcus epidermidis , and no cytotoxicity for human keratinocyte HaCaT cells. However, many other reports in literature have shown controversial results about the toxicity of GO demanding further investigation. Furthermore, the synergic effect of GO with other divalent cations with intrinsic antibacterial and cytotoxic activity such as Zn 2+ has not been explored yet. Thus, here, two commercially available sodium alginates were characterised and utilized in the synthesis of zinc alginate films with GO following the same chemical route reported for the calcium alginate/GO composites. The results of this study showed that zinc release, water sorption/diffusion and wettability depended significantly on the type of alginate utilized. Furthermore, Zn 2+ and GO produced alginate films with increased water diffusion, wettability and opacity. However, neither the combination of GO with Zn 2+ nor the use of different types of sodium alginates modified the antibacterial activity and cytotoxicity of the zinc alginates against these Gram-positive pathogens and human cells respectively.

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“…6 To this purpose, bio-inspired approaches that look at nature's strategies against pathogen infections, can provide safe and high performance solutions. 7,8 Accordingly, eumelanins, negatively charged and hydrophobic pigments found ubiquitously in many parts of living beings 9 have been gaining great attention as bio-available compounds with huge technological potential. 10 Eumelanins are truly multifunctional biopolymers, 11 performing several biological functions such as photoprotection, photosensitization, free radical quenching, metal ion chelation and even intrinsic antimicrobial efficacy and biolm inhibition without any photosensitization.…”

Section: Introductionmentioning

confidence: 99%

Bioinspired hybrid eumelanin–TiO₂antimicrobial nanostructures: the key role of organo–inorganic frameworks in tuning eumelanin's biocide action mechanism through membrane interaction

et al. 2018

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Synthesis and antimicrobial properties of Zn-mineralized alginate nanocomposites

Cited by 44 publications

References 38 publications

Novel composite zinc-alginate hydrogels with activated charcoal aimed for potential applications in multifunctional primary wound dressings

Novel composite zinc-alginate hydrogels with activated charcoal aimed for potential applications in multifunctional primary wound dressings

Graphene oxide in zinc alginate films: Antibacterial activity, cytotoxicity, zinc release, water sorption/diffusion, wettability and opacity

Bioinspired hybrid eumelanin–TiO₂antimicrobial nanostructures: the key role of organo–inorganic frameworks in tuning eumelanin's biocide action mechanism through membrane interaction

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Synthesis and antimicrobial properties of Zn-mineralized alginate nanocomposites

Cited by 44 publications

References 38 publications

Novel composite zinc-alginate hydrogels with activated charcoal aimed for potential applications in multifunctional primary wound dressings

Novel composite zinc-alginate hydrogels with activated charcoal aimed for potential applications in multifunctional primary wound dressings

Graphene oxide in zinc alginate films: Antibacterial activity, cytotoxicity, zinc release, water sorption/diffusion, wettability and opacity

Bioinspired hybrid eumelanin–TiO2antimicrobial nanostructures: the key role of organo–inorganic frameworks in tuning eumelanin's biocide action mechanism through membrane interaction

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Bioinspired hybrid eumelanin–TiO₂antimicrobial nanostructures: the key role of organo–inorganic frameworks in tuning eumelanin's biocide action mechanism through membrane interaction