Synthesis and Antimicrobial Evaluation of Novel Polyfused Heterocycles‐Based Quinolone

Recent advances in the chemistry of 2-chloroquinoline-3-carbaldehyde and related analogs

“…The S-enantiomer was found to be more active than the racemic mixture and had pharmacokinetic properties amenable to systemic use. 31 In continuation of the previous researches on the synthesis and reactions of quinolines, [43][44][45][46][47] we described herein the literature survey of different strategies developed so far for the synthesis of 2-chloroquinoline-3-carbaldehyde and their analogs as well as to highlight their reactivity and their use as building blocks in the synthesis of variable heterocyclic systems of potent biological properties.…”

Selective Synthesis Dispiro[indoline‐3,2′‐pyrrolidine‐3′,3″‐quinoline] Derivatives and Spiro[imidazole‐4,3′‐quinoline] Derivatives via 1,3‐Dipolar Cycloaddition Reaction

“…Reactions were monitored by thin‐layer chromatography and preparative layer chromatography carried out on 0.2–0.4 mm silica gel 60 F254 (Merck) plates using UV light (254 and 366 nm) for detection. (Z)‐7‐Methoxy‐3‐(4‐methoxybenzylidene)quinoline‐2,4(1 H ,3 H )‐dione ( 3 ) was prepared according to the previously reported method .…”

Pyrimido[5,4‐c]quinolines: Synthesis from 3,4‐Di‐functionallized Quinoline, Reactivity and Biological Activities

“…Synthesis pyrimido [5,4- ). [49] The starting material, 4-hydroxy-1-phenylquinolin-2(1H)-one 230, was synthesized by reacting diphenylamine 179 with diethylmalonate 155 under reflux conditions in diphenylether. ).…”

“…Further in‐situ oxidation of dihydropyrimido[5,4‐ c ]‐quinoline 228 with H 2 O 2 yielded the pyrimido[5,4‐ c ]‐quinoline 229 (Scheme 32). [49] …”