Synthesis and antimicrobial evaluation of a pyrazoline-pyridine silver(I) complex: DNA-interaction and anti-biofilm activity

Abstract

The emergence of resistant bacterial strains mainly due to misuse of antibiotics has seriously affected our ability to treat bacterial illness, and the development of new classes of potent antimicrobial agents is desperately needed. In this study, we report the efficient synthesis of a new pyrazolinepyridine containing ligand L1 which acts as an NNdonor for the formation of a novel silver (I) complex 2. The free ligand did not show antibacterial activity. High potency was exhibited by the complex against three Gram-negative bacteria, namely Escherichia coli, Pseudomonas aeruginosa and Acinetobacter baumanii with the minimum inhibitory concentration

Synthesis of 2‐Pyrazolines from Hydrazines: Mechanisms Explained

“…Matiadis et al synthesized pyrazoline 34 c via the cyclization reaction between a curcuminoid compound 34 a and 2-hydrazinopyridine 34 b in ethanol under reflux condition (Scheme 34). [49] In another study by our group, various 1,3,5-trisubstituted 2-pyrazolines were prepared without catalyst in the cyclization step. [50] The prepared chalconic compound…”

“…Matiadis et al synthesized pyrazoline 34 c via the cyclization reaction between a curcuminoid compound 34 a and 2‐hydrazinopyridine 34 b in ethanol under reflux condition (Scheme 34). [49] …”

Synthesis and Biological Evaluation of Hydroxylated Monocarbonyl Curcumin Derivatives as Potential Inducers of Neprilysin Activity

“…Elemental analyses were performed using a PerkinElmer 2400 CHNS 100V Organic Elemental Analyzer (Waltham, MA, USA). Compounds 5-7 were synthesised as described previously [27][28][29].…”

“…As part of an effort to develop improved curcuminoids, the design of monocarbonyl analogs of curcumin (MACs) as a highly attractive alternative class of compounds was chosen [27][28][29]. MACs usually demonstrate higher potency than the diketo-curcuminoid counterparts, they are more readily produced, more stable, and they exhibit improved pharmacological profiles [39,40].…”

Pyrazol(in)e Derivatives of Curcumin Analogs As a New Class of Anti- Trypanosoma Cruzi Agents

“…Pyrazolines 2a,b were synthesized using 2-hydrazinopyridine in neat ethanol under reflux for three days. In particular, the synthesis and characterization of 2a has been reported previously [27]. Fluorophenyl derivatives 3a-c were prepared using hydrochloric 4fluorophenyl hydrazine in the presence of sodium ethoxide in ethanol.…”