Synthesis and antimicrobial evaluation of amide derivatives of benzodifuran-2-carboxylic acid

Soni, Jigar N.; Soman, Shubhangi S.

doi:10.1016/j.ejmech.2014.01.026

Cited by 29 publications

(13 citation statements)

References 18 publications

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“…The incidence of fungal infections has increased significantly in the past 25 years [1]. Human beings are colonized by a diverse and complex collection of microorganisms, contributing all of them to host nutrition, development of the immune system, response to pathogens and mucosal cell differentiation and proliferation [2].…”

Section: Introductionmentioning

confidence: 99%

Probiotics for Prevention and Treatment of Candidiasis and Other Infectious Diseases: Lactobacillus spp. and Other Potential Bacterial Species

Silva¹,

Rossoni²,

CamposJunqueira³

et al. 2016

Probiotics and Prebiotics in Human Nutrition and Health

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The resident microbiota in the human body, such as the oral cavity, gastrointestinal tract and genitourinary tract, is able to provide resistance to disease. However, imbalances in the microbial components can promote the growth of opportunistic microorganisms, such as yeasts of genus Candida. Fungal infections present as a major cause of infectious diseases and the microorganisms of genus Candida are the most frequently isolated pathogenic fungi in human fungal infections. Bacillus spp. and Lactobacillus spp. are bacteria that have probiotic effects used in commercially available products and in studies that aim for the development of probiotics able to inhibit the microbial pathogenicity and restore the balance of resident microbiota. Thus, with increasing fungus resistance to the use of antifungal agents, which are capable of causing serious side effects to the host organism unable to destroy the target microorganism, it becomes important to develop therapeutic and/or prophylactic alternatives that have a different and an effective mechanism of action with capacity to combat fungal infections without harming the patient. Probiotic bacteria provide an alternative strategy for the prevention and treatment of candidiasis and other infectious diseases.

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Section: Introductionmentioning

confidence: 99%

Probiotics for Prevention and Treatment of Candidiasis and Other Infectious Diseases: Lactobacillus spp. and Other Potential Bacterial Species

Silva¹,

Rossoni²,

CamposJunqueira³

et al. 2016

Probiotics and Prebiotics in Human Nutrition and Health

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“…[11][12][13] Some natural products with benzofuran scaffold display a variety of biological activities like anti-inflammatory, antibacterial, antitumor, antitubercular activities. [14][15][16][17] Some benzodifuran derivatives shows various biological activities like antimicrobial, 18 antifeedant 19 and anti-inflammatory. 20 Heterocyclic nuclei when coupled with different substituents in different reaction sequesces like Buchwald, Suzuki, peptide, oxidation or reduction reactions results novel heterocycles show variety of biological activities.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Antimicrobial Screening of 5-(Substituted Phenyl)-N-(2-Oxo-2-(Substituted Phenyl)ethyl)-N-Methylfuran-2-Sulfonamide Derivatives

Desmukh¹,

Pawar²,

Pansare³

et al. 2019

ECB

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We synthesized substituted furansulfonamide compounds and developed reaction conditions for a series of 5-(substituted phenyl)-N-(2oxo-2-(substituted phenyl)ethyl)-N-methylfuran-2-sulfonamide derivatives (4a-4m). We have optimized methodology for targets from milligram scale to multi gram scale. The structure of synthesized compounds were elucidated and confirmed by 1H NMR, 13C NMR, LCMS and purity was checked by HPLC. All the synthesized final compounds (4a-4m) are screened for antimicrobial activity (minimum inhibitory concentration) against a series of strains of Bacillus subtillis, Staphylococcus aureus and Escherichia coli for antibacterial activity and against the strains of Candida albicans, Aspergillus flavus and Aspergillus niger for antifungal activity. The results of antimicrobial screening data revealed most of compounds (4a-4m) showed moderate to promising microbial inhibitions.

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“…The benzodifurans caffold can be easily functionalised to finely modulate its absorption-emission spectral properties and the resulting compounds used for severala pplications,f or example, as efficient organic dyes in solar cells, [1] or as building blocks for optoelectronic devices [2] or transistors. [3] Moreover, benzodifurand erivatives have shown variousb iologicala ctivities, as antibacterial/antifungal, [4] antifeedant, [5] vasodilator and anti-inflammatory-in particular, as potent 5-HT2A/2C serotonin receptor agonists [6,7] -as wella sa ntiviral agents. [8] In particular,t he antiviral activity of two benzodifuran compounds was investigated around3 0years ago by Viano et al,w ho demonstrated their significant inhibitory activity against DNA and RNA viruses in concentrations ranging from 15 to 30 mm.T his bioactivity was attributed to the ability of these compounds to bind DNA and inhibit its synthesis, with af avourable ratio between antiviral activity and inhibition of host-cell DNA synthesis.…”

Section: Introductionmentioning

confidence: 99%

Benzodifuran Derivatives as Potential Antiproliferative Agents: Possible Correlation between Their Bioactivity and Aggregation Properties

et al. 2016

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To further explore the properties and bioactivity of benzodifurans, three compounds in this class were synthesised and characterised using spectroscopic and spectrometric techniques, as well as SEM and thermogravimetric analysis. The synthesised compounds showed interesting antiproliferative activity on different human cancer cells (HeLa, Hep‐G2, WM266), whereas no relevant cytotoxic effect was observed on healthy control cells. To study the possible mechanism of action of the benzodifurans, their ability to bind various model DNA systems, their aggregation properties, and their ability to bind biologically relevant metal ions was evaluated. The molecules were found to form monodisperse nanoaggregates stable at physiological temperature, which are likely related to the observed bioactivity.

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Synthesis and antimicrobial evaluation of amide derivatives of benzodifuran-2-carboxylic acid

Cited by 29 publications

References 18 publications

Probiotics for Prevention and Treatment of Candidiasis and Other Infectious Diseases: Lactobacillus spp. and Other Potential Bacterial Species

Probiotics for Prevention and Treatment of Candidiasis and Other Infectious Diseases: Lactobacillus spp. and Other Potential Bacterial Species

Synthesis and Antimicrobial Screening of 5-(Substituted Phenyl)-N-(2-Oxo-2-(Substituted Phenyl)ethyl)-N-Methylfuran-2-Sulfonamide Derivatives

Benzodifuran Derivatives as Potential Antiproliferative Agents: Possible Correlation between Their Bioactivity and Aggregation Properties

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