2010
DOI: 10.1002/cjoc.201090332
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Synthesis and Antimicrobial Activity of Quinazolin‐4(3H)‐ones Incorporating Sulfonamido‐4‐thiazolidinone

Abstract: Some new derivatives 7-chloro-2-[2-(2,6-dichlorophenyl)amino]benzyl-3-[4-(2-substituted phenyl-4-oxothiazolidin-3-yl)phenyl]sulfonamido-quinazolin-4(3H)-ones 5a -5l were synthesized from 2-[2-(2,6-dichlorophenyl)amino]phenyl acetic acid via acid chloride, benzoxazinone, amino quinazolin-4(3H)-one and Schiff base formation. The synthesized compounds were screened for in vitro antibacterial and antifungal activities by broth micro dilution method. Some of the Schiff base as well as 4-thiazolidinone derivatives s… Show more

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Cited by 5 publications
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“…Compounds with the structure of AC=NB are known as Schiff bases, which arouse considerable interest due to their antifungal, anticancer and antibacterial activities [1][2][3][4][5] . The Schiff bases compounds can be synthesized from the condensation of primary amines and active carbonyl groups.…”
Section: Introductionmentioning
confidence: 99%
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“…Compounds with the structure of AC=NB are known as Schiff bases, which arouse considerable interest due to their antifungal, anticancer and antibacterial activities [1][2][3][4][5] . The Schiff bases compounds can be synthesized from the condensation of primary amines and active carbonyl groups.…”
Section: Introductionmentioning
confidence: 99%
“…
INTRODUCTIONCompounds with the structure of AC=NB are known as Schiff bases, which arouse considerable interest due to their antifungal, anticancer and antibacterial activities [1][2][3][4][5] . The Schiff bases compounds can be synthesized from the condensation of primary amines and active carbonyl groups.Taurine (2-aminoethane sulfonic acid), which belongs to an organic acid widely distributed in animal tissues, is a nonprotein β-amino acid, playing an important role in many physiological processes i.e., regulation of cardiovascular responses and neuronal excitability, maintenance of structure and function of photoreceptors, modulation of neurotransmitter and hormone release [6][7][8][9] .
…”
mentioning
confidence: 99%