Synthesis and antimicrobial activity of sulfanylamide-containing copper(II) and nickel(II) salicylidenethiosemicarbazidates

Abstract

A series of streptocide-, sulfacyl-, norsulfazole-, ethazole-, sulfadimezine-, and sulfapyridazine-containing copper(II) and nickel(II) salicylidenethiosemicarbazidates and salicylidene-4-phenilthiosemicarbazidates possessing high antimicrobial activity has been synthesized. The composition and probable structures of the obtained coordination compounds are proposed based on elemental analysis and magnetochemical, IR spectroscopy, and thermogravimetric data. The dependence of the antimicrobial activity of compounds on the nature of the central atom, sulfanilamide, and phenyl radicals in the thiosemicarbazide fragment of azomethine has been studied with respect to ten species of staphylococcus, streptococcus, and intestine bacillus strains. The maximum activity was exhibited by norsulfazole-and sulfacyl-containing Cu(II) salicylidenethiosemicarbazidate and Cu(II) salicylidene-4-phenilthiosemicarbazidate.

In vitro antileukemia, antibacterial and antifungal activities of some 3d metal complexes: Chemical synthesis and structure – activity relationships

“…Antibacterial bioassay (Table III) The antibacterial activity of complexes XXI-XXIV and also of their prototype Furaciline was determined under liquid nutritive environment [2% of peptonate bullion (pH 7.0)] using successive dilutions method [11,12]. Staphylococcus aureus (Wood-46, Smith, 209-P), Staphylococcus saprophyticus, Streptococcus faecalis, Escherichia coli (O-111), Salmonella typhimurium, Salmonella enteritidis, Klebsiella pneumoniaie, Pseudomonas aeruginosa, Proteus vulgaris and Proteus mirabilis standard stems were used as reference culture for in vitro experiment.…”

Synthesis and Characterization of Some New Cu(II), Ni(II) and Zn(II) Complexes with Salicylidene Thiosemicarbazones: Antibacterial, Antifungal and in Vitro Antileukemia Activity

“…The tentative assignments of the significant IR spectral bands of H 2 L 1 – H 2 L 10 and their Cu(II), Ni(II) and Zn(II) complexes are presented in Table 1. It has been established that the substituted salicylaldehyde thiosemicarbazones of complexes 1 – 14 behave as monodeprotonated tridentate ligands and are coordinated to the central ions through deprotonated phenolic oxygen atom, azomethinic nitrogen atom and sulphur atom forming five- and six-membered metalocycles [9,20,21].…”

“…Indeed, copper complexes containing tridentate ONS Schiff bases as well as salicyliden thiosemicarbazones have been found as effective inhibitors of cell proliferation. We have started a program directed toward the synthesis of different classes of anticancer, antibacterial and antifungal agents designed with complexes of a transition metal and an organic ligand [21,22,23,24].…”

Synthesis, Characterization, Crystal Structure and Antimicrobial Activity of Copper(II) Complexes with the Schiff Base Derived from 2-Hydroxy-4-Methoxybenzaldehyde

“…The antibacterial activity of complexes and also of their prototype furaciline has been determined under liquid nutritive environment [2% of peptone bullion (pH 7.0)] using successive dilutions method [ 67 , 68 , 69 ]. Escherichia coli , Salmonella enteritidis , Staphylococcus aureus , Enterococcus stems were used as reference culture for in vitro experiment.…”