Synthesis and antimicrobial activity of some new N-glycosides of 2-thioxo-4-thiazolidinone derivatives

Metwally, Nadia H.; Abdalla, Mohamed A. Y.; Mosselhi, Mosselhi Abdel Nabi; El-Desoky, Ebrahim Adel

doi:10.1016/j.carres.2010.04.011

Cited by 47 publications

(22 citation statements)

References 28 publications

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“…1 H NMR spectra of (7) and (8) showed in each case a doublet signals at δ 6.67, 6.73 for compound (7) and at δ 6.74, 6.67 for compound (8) assigned to the anomeric proton of the ribose moiety with spin-spin coupling constant (J 1',2' ) and (J 1'',2'' ) equal to 7.5 Hz, which confirms the β-anomeric configuration. While confirms the a-anomeric configuration showed spin-spin coupling constant (J 1',2' ) and (J 1'',2'' ) equal to 3.4 Hz, which confirms the a-anomeric configuration for compound (8) (Mosselhi, 1993;Mosselhi, 1999;Mosselhi & Seliger, 2001;Mosselhi & Break, 2011;Break et al, 2010;Metwally et al, 2010;Breaket al, 2013 andKhalil, 2006). The 1 H NMR spectra of nucleosides free showed a doublet signals at δ 6.41, 6.46 for compound (9) spinspin coupling constant (J 1',2' ) and (J 1'',2'' ) equal to 7.5 Hz -anomeric configuration and at δ 6.43, 6.47 for compound (10) assigned to spin-spin coupling constant (J 1',2' ) and (J 1'',2'' ) equal to 4.25 Hz, which confirms the a-anomeric configuration.…”

Section: Resultssupporting

confidence: 61%

Synthesis of the Novel 3-Benzotriazole-5-yl difluoromethyl-5-trifluoromethyl benzotriazole Nucleosides

Break¹

2015

IJC

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Triazole ring is a quite important five-membered heterocycle with three nitrogen atoms, possesses aromaticity and is an electron rich system. Triazole derivatives have been frequently becoming clinical drugs or candidates for the treatment of various types of diseases. Synthesis of the novel of 3-Benztriazole-5-yl difluoromethyl-5-trifluoromethyl benztriazole compound (3). Synthesis and chara-cterization of two new benzotriazole nucleosides with good yields by silyation method.

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Section: Resultssupporting

confidence: 61%

Synthesis of the Novel 3-Benzotriazole-5-yl difluoromethyl-5-trifluoromethyl benzotriazole Nucleosides

Break¹

2015

IJC

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“…44). The p-bromophenyl substituted derivative showed the highest efficiency against E. coli (MIC ¼ 143 mg/mL) but was 3 times less active than tetracycline (MIC ¼ 39 mg/mL) [84].…”

Section: Abdelmentioning

confidence: 97%

Synthetic approaches, structure activity relationship and biological applications for pharmacologically attractive pyrazole/pyrazoline–thiazolidine-based hybrids

Havrylyuk

Roman

Lesyk

2016

European Journal of Medicinal Chemistry

134

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The features of the chemistry of 4-thiazolidinone and pyrazole/pyrazolines as pharmacologically attractive scaffolds were described in a number of reviews in which the main approaches to the synthesis of mentioned heterocycles and their biological activity were analyzed. However, the pyrazole/pyrazoline-thiazolidine-based hybrids as biologically active compounds is poorly discussed in the context of pharmacophore hybrid approach. Therefore, the purpose of this review is to summarize the data about the synthesis and modification of heterocyclic systems with thiazolidine and pyrazoline or pyrazole fragments in molecules as promising objects of modern bioorganic and medicinal chemistry. The description of biological activity was focused on SAR analysis and mechanistic insights of mentioned hybrids.

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“…The compounds having a thiazolidinone nucleus are of interest due to their broad spectrum of biological activities such as bactericidal, fungicidal, antimicrobial, antiproliferative, antiviral, anticonvulsant, anticancer, and anti-inflammatory activities (Vicini et al ., 2008; Wang et al ., 2011; Lv et al ., 2010; Metwally et al ., 2010; Balzarini et al ., 2009; Havrylyuk et al ., 2009; Subtelna et al ., 2010; Mushtaque et al ., 2012). …”

Section: Introductionmentioning

confidence: 99%

Microwave-assisted synthesis of some hybrid molecules containing penicillanic acid or cephalosporanic acid moieties and investigation of their biological activities

et al. 2013

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Ethyl 4-amino-2-fluorophenylpiperazin-1-carboxylates containing a 1,3-oxazol(idin)e, 5-thioxo-1,2,4-triazole, 1,3,4-thiadiazole, 5-thioxo-1,3,4-oxadiazole, or 1,3-thiazole nucleus were obtained starting from ethyl piperazine-1-carboxylate (1) by several steps. The treatment of amine, 3 or hydrazide, 9 with several aromatic aldehydes generated the corresponding arylmethyleneamino (3a–f) or arylidenehydrazino (12a–c) compounds. The Mannich reaction between the 1,2,4-triazole or 1,3,4-oxadiazole compounds and 7-aca produced cephalosporanic acid derivatives. Penicillanic acid derivatives were obtained when 6-apa was used in the Mannich reactions. The synthesized compounds were screened for their antimicrobial, antilipase, and antiurease activities. Some of them were found to possess good-moderate antimicrobial activity against the test microorganisms. Two compounds exhibited antiurease activity, and four of them displayed antilipase activity.

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Synthesis and antimicrobial activity of some new N-glycosides of 2-thioxo-4-thiazolidinone derivatives

Cited by 47 publications

References 28 publications

Synthesis of the Novel 3-Benzotriazole-5-yl difluoromethyl-5-trifluoromethyl benzotriazole Nucleosides

Synthesis of the Novel 3-Benzotriazole-5-yl difluoromethyl-5-trifluoromethyl benzotriazole Nucleosides

Synthetic approaches, structure activity relationship and biological applications for pharmacologically attractive pyrazole/pyrazoline–thiazolidine-based hybrids

Microwave-assisted synthesis of some hybrid molecules containing penicillanic acid or cephalosporanic acid moieties and investigation of their biological activities

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