Synthesis and antimicrobial activity of novel 5-(1-adamantyl)-2-aminomethyl-4-substituted-1,2,4-triazoline-3-thiones

Crystal structure of (Z)-3-(adamantan-1-yl)-1-(3-chlorophenyl)-S-benzylisothiourea, C24H27ClN2S

“…Moreover, several adamantane-based drugs are currently used as useful therapies for the control central nervous disorders [21,22]. In addition, potent antimicrobial [23][24][25], anticancer [26,27], anti-inflammatory [28,29] and hypoglycemic [30] activities were reported for numerous adamantane-based derivatives. The present investigation describes the synthesis and the single crystal X-ray structural characteristics of the title adamantane-isothiourea hybrid molecule as potential chemotherapeutic agent.…”

Crystal structure of 1-(adamantan-1-yl)-3-(3-chlorophenyl)thiourea, C17H21ClN2S

“…As a part of our current research interest in the chemotherapeutic properties of adamantane derivatives [17][18][19] and the molecular structural of adamantyl thiourea analogues [20][21][22], we report herein the synthesis and crystal title structure. The asymmetric unit cell of the title structure contains two independent molecules.…”

Crystal structure of 1-(adamantan-1-yl)-3-(4-bromophenyl)thiourea, C17H21BrN2S

“…In addition, thiourea derivatives were reported to display marked antitumor [13], anti-HIV [14], antimalarial [15] and antimicrobial [16] activities. As a part of our current research interest in the pharmacological [17][18][19] and structural [20][21][22] properties of adamantane derivatives, we report herein the synthesis and crystal structure of the title compound as bioactive agent and as precursor for adamantanebased chemotherapeutic agents. The asymmetric unit of the title structure contains one independent molecule.…”