Synthesis and Antimicrobial Activity of Some Novel [4‐(1,2,3‐thiadiazol‐4‐yl)phenoxy]methylene anchored 1,3,4‐triazoles and 1,3,4‐thiadiazoles

Abstract

A series of novel [4-(1,2,3-thiadiazol-4-yl)phenoxy]methylene anchored 1,3,4-triazoles (8a-h) and 1,3,4-thiadiazoles (9a-i) were synthesized from thiosemicarbazide (7a-j). The structures of these newly synthesized compounds were confirmed on the basis of IR, 1 H-NMR, mass spectral techniques, and elemental analysis. The in vitro antimicrobial screenings of the synthesized compounds were carried out against four bacterial pathogens, namely Staphylococcus aureus, Streptococcus pyogenes, Escherichia coli, Pseudomonas aeruginosa and three fungal pathogens Candida albicans, Aspergillus niger and Aspergillus clavatus, using broth microdilution minimum inhibitory concentration method. The compounds 7d, 7j, 8a, 9a, 9b, and 9i exhibited promising antibacterial activity against the tested strains, whereas some compounds were found to be active against one of the tested bacterial strains.

Realizing Over 13% Efficiency in Green‐Solvent‐Processed Nonfullerene Organic Solar Cells Enabled by 1,3,4‐Thiadiazole‐Based Wide‐Bandgap Copolymers

“…Herein, we design and synthesize two novel wide‐bandgap copolymers based on 1,3,4‐thiadiazole (TDZ) and benzo[1,2‐b:4,5‐b′]dithiophene (BDT), PBDT‐TDZ and PBDTS‐TDZ ( Figure ), for fabricating highly efficient NF‐OSCs. Thiadiazole cycles have been widely studied in pharmaceutical chemistry due to their remarkably broad spectrum of biological activities . As one of the thiadiazole isomers, TDZ associates with conjugated p and π electrons as well as distinct regions of positive and negative charges .…”

An expedient and straightforward solvent‐free synthesis of 1,8‐dioxo‐octahydroxanthenes using eco‐friendly aluminized polyborate catalyst

“…To overcome such problems there is still demand to develop novel methodologies with greener conditions. The biological importance of xanthene, need of newer environmental benign protocol and in continuation to our work [ 51–53 ] herein, we report aluminized polyborate as mild solid acid catalyzed expedient and efficient synthesis of 1,8‐dioxo‐octahydroxanthenes using 2 moles of dimedone and 1 mole of aromatic aldehyde under solvent‐free condition at 100‐110°C with excellent product yield in shorter time (Scheme 1).…”

Novel 6‐Morpholino‐9H‐purine Derivatives: Synthesis, Pharmacological and In Silico Evaluation

“…[3][4][5][6] The privileged scaffold of purine is one amongst the nitrogen containing heterocycles whose framework exists in nature adenine and guanine and has enormous biological significance with an array of functions in living species, thus creating curiosity in the synthesis of their analogues. [7][8][9] Purines have also reported to exhibit potential activity as antibacterial, [10] antifungal, [11] anti-inflammatory, [12] antihyperglycemic, [13] cytotoxic [14] and many others. The presence of appropriate substituents on C-6, C-8 and N-9 positions of the purine scaffold are vital for the expression of enhanced activity in non nucleoside analogues [15] (Figure 1).…”