Synthesis and Antimicrobial Activity of Complexes Based on 4-aryl-2-hydroxy-4-oxo-2-butenoic Acid N-heterylamides

Abstract

Reaction of 4-aryl-2-hydroxy-4-oxo-2-butenoic acid N-hetarylamides with copper, zinc, and cadmium dichlorides led to the formation of bis[3-aryl-1-(N-hetaryl)carboxamido-1,3-propanedionato]copper, -zinc, and -cadmium, respectively. Compounds with high antimicrobial activity were found among these products. 3890091-150X/08/4207-0389

Synthesis and hypoglycemic and anti-inflammatory activity of metal complexes of 4-aryl-2-hydroxy-4-oxo-2-butenoic acid N-heterylamides

“…Thermogravimetric studies indicated that the N-heterylamides I coordinated to the metals as bidentate O-O ligands. IR spectra of V -VII also confirmed their structures and agreed with the literature properties of chelate complexes II -IV [6,7].…”

“…We prepared previously complexes of copper, zinc, and cadmium with N-heterylamides of 4-aryl-2-hydroxy-4-oxo-2-butenoic acids (I) [6,7]. High antimicrobial activity was observed for the products II -IV (Scheme).…”

Synthesis of 4-Aryl-2-hydroxy-4-oxo-N-{4-[(1,3-thiazol-2-yl)- sulfamoyl]phenyl}but-2-eneamides

“…1 H NMR spectra were registered on a Bruker AM-300 spectrometer (300 MHz) in DMSO-d 6 , internal reference TMS. IR spectra were recorded on a Specord M-80 spectrometer from KBr pellets.…”

Synthesis and Structure (Z)-N-Aryl-2-hydroxy-4-oxo-4-phenylbut-2-enamides

“…These polyfunctional reagents show high reactivity due to the presence of several reaction sites in their structure [1,2]. They can act as C-nucleophiles and carbonyl electrophiles in the reactions, being promising starting materials for the synthesis of a variety of acyclic and heterocyclic compounds [1][2][3][4].…”