Synthesis and Antimicrobial Activity of Some 1,3‐Disubstituted Indeno[1,2‐c]pyrazoles

Abstract

in Wiley Online Library (wileyonlinelibrary.com). [1,2-c]pyrazoles, possessing 4-substituted thiazole moiety at position-1 derived from 2-acyl indane-1,3-diones, has been described. These compounds and their precursor were screened for their antibacterial (Staphylococcus aureus, Bacillus subtilis, Escherichia coli) and antifungal (Aspergillus niger, Candida albicans) activities. Synthesis of new 3-alkyl indeno

Convenient and efficient synthesis of novel 11H-benzo[5,6][1,4]thiazino[3,4-a]isoindol-11-ones derived from 2-bromo-(2/3-substitutedphenyl)-1H-indene-1,3(2H)-diones

“…2-bromo-(2/3-substitutedphenyl)-1 H -indene-1,3(2 H )-diones (2) and 5-substituted 2-aminobenzenethiols (4) were obtained as outlined in Schemes 1 and 2 , respectively. The synthesis of 2 was carried out by the reaction of phthalide with appropriate 2/3-substituted benzaldehyde in the presence of ethyl acetate and sodium methoxide, 50,51 which upon subsequent bromination in Br 2 /chloroform afforded the corresponding 2-bromo-(2/3-substitutedphenyl)-1 H -indene-1,3(2 H )-diones (2) in good yields. 52 The synthesis of 5-substituted 2-aminobenzenethiols (4) began with 4-substituted anilines as the starting materials, which on reaction with sodium thiocyanate in Br 2 /glacial CH 3 COOH afforded the corresponding 2-amino-6-substituted benzothiazoles (3) in good yields.…”

“…The compound (2) was prepared by the reaction of phthalide with appropriately substituted benzaldehyde in presence of ethyl acetate and sodium methoxide, 50,51 which upon subsequent bromination in Br 2 /chloroform afforded the corresponding 2-bromo-(2/3-substitutedphenyl)-1 H -indene-1,3(2 H )-diones (2) in good yields. 52 …”

Systematic Review on Thiazole Compounds as Nanoparticles: Chemistry, Synthesis, Antimicrobial Activities, Therapeutic Investigation

“…Rajni et al have synthesized some thiazole derivatives (10) with potent antimicrobial activity against S. aureus, B.subtilis and E.coli [107]. Karale et al have synthesized (11) and evaluated them against B.subtilis, S.aureus and E.coli [108]. Compound containing catechol unit improved Gram-negative inhibition [109].…”

Indane-1,3-Dione: From Synthetic Strategies to Applications

“…A relevant example of this strategy has been reported in 2011 with a study devoted to the antimicrobial activity of 1,3-disubstituted indeno [1,2-c]pyrazoles [392]. Pyrazoles are an important class of pharmaceutical compounds.…”