Synthesis and Antimicrobial Activity of Novel Polycyclic Thienopyridazine Derivatives

Fayed, Ahmed A.; Yousif, Mahmoud N. M.; Abdelgawad, Taha Taha; Amr, Abd El‐Galil E.; Yousif, N. M.; Gad, F. A.

doi:10.1007/s10593-019-02534-1

Cited by 4 publications

(1 citation statement)

References 12 publications

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“…Nitrogen-containing heterocyclic compounds, a very important class of heterocycles, are of interest to organic and medicinal chemists because of their occurrence in natural products as well as diverse pharmaceutical and biological activities. − Notably, cinnolines are one of the vital N -containing heterocycles, known for their privileged anti-inflammatory, antibacterial, anticancer, and antimicrobial activities. Also, their derivatives have exhibited remarkable properties in n-channel semiconductors and cell imaging .…”

Section: Introductionmentioning

confidence: 99%

Diphenhydramine Hydrochloride–CuCl as a New Catalyst for the Synthesis of Tetrahydrocinnolin-5(1H)-ones

et al. 2023

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The current study deals with the synthesis and characterization of a novel catalyst made from diphenhydramine hydrochloride and CuCl ([HDPH]Cl−CuCl). The prepared catalyst was thoroughly characterized using various techniques, such as 1 H NMR, Fourier transform-infrared spectroscopy, differential scanning calorimetry, and thermogravimetric analysis and derivative thermogravimetry. More importantly, the observed hydrogen bond between the components was proven experimentally. The activity of this catalyst was checked in the preparation of some new derivatives of tetrahydrocinnolin-5(1H)ones via a multicomponent reaction between dimedone, aromatic aldehydes, and aryl/alkyl hydrazines in ethanol as a green solvent. Also, for the first time, this new homogeneous catalytic system was effectively used for the preparation of unsymmetric tetrahydrocinnolin-5(1H)-one derivatives as well as mono-and bis-tetrahydrocinnolin-5(1H)-ones from two different aryl aldehydes and dialdehydes, respectively. The effectiveness of this catalyst was further confirmed by the preparation of compounds containing both tetrahydrocinnolin-5(1H)one and benzimidazole moieties from dialdehydes. The one-pot operation, mild conditions, rapid reaction, and high atom economy, along with the recyclability and reusability of the catalyst, are other notable features of this approach.

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Section: Introductionmentioning

confidence: 99%

Diphenhydramine Hydrochloride–CuCl as a New Catalyst for the Synthesis of Tetrahydrocinnolin-5(1H)-ones

et al. 2023

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Synthesis and Biological Activity of Triacetonamine

et al. 2020

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Recent Advances in Chemistry and Biological Activity of 2,6-Diphenyl Piperidines

Mahmoud

2022

MROC

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: The review discusses different methods for preparation of 2,6-diphenyl-piperidin-4-one derivatives. 2,6-Diphenyl-piperidin-4-one is prepared from aromatic aldehyde and acetone in ammonium acetate. Reaction of 1-phenylsulfinylpropan-2-one or 1-(4-chlorophenylsulfinyl)propan-2-one, aromatic aldehyde and ammonium acetate gives a series of 2,6-diaryl-2,3-dihydro-1H-pyridin-4-one 6a,b. 4-Phenyl-2-amino-1,3-butadienes reacts with N-allyl benzaldimine through Diels-Alder reaction to afford 2,6-diphenyl-4-piperidinone derivative 7. Also, reactions of 2,6-diphenyl-piperdin-4-one are discussed. The reactions of latter compounds can be on nitrogen atom or carbonyl function group or methylene group adjacent to carbonyl group. In addition, different applications of 2,6-diphenyl-piperidin-4-one are summarized.

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Synthesis and Antimicrobial Activity of Novel Polycyclic Thienopyridazine Derivatives

Cited by 4 publications

References 12 publications

Diphenhydramine Hydrochloride–CuCl as a New Catalyst for the Synthesis of Tetrahydrocinnolin-5(1H)-ones

Diphenhydramine Hydrochloride–CuCl as a New Catalyst for the Synthesis of Tetrahydrocinnolin-5(1H)-ones

Synthesis and Biological Activity of Triacetonamine

Recent Advances in Chemistry and Biological Activity of 2,6-Diphenyl Piperidines

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