Synthesis and Antimicrobial Activity of 2-R 5-oxo 5-H 6 -carbohydrazin 7-phenyl 1,3,4-thiadiazolo-[3,2-a] pyrimidine

Abstract

The synthesis of 2-R 5-oxo 5-H 6 -carbohydrazin 7-phenyl 1, 3,4-thiadiazolo-[3,2-a] pyrimidine is described. This compound exhibits a broad spectrum of antimicrobial action and can be useful in the search for new antimicrobial drugs.Reactions of 2-R 5 -Oxo 5-H 6-EthylCarboxilate 7-phenyl -1, 3,4 -Thiadiazolo-[3,2-a] pyrimidine with hydrazine produce 2-R 5-oxo 5-H 6 -carbohydrazin 7-phenyl 1,3,4-thiadiazolo-[3,2-a] pyrimidine. The structures of the compounds obtained are set NMR, 13C, IR-spectroscopy.

Reaction 2-R 5-oxo 5-H 6-Ethylcarboxylate 7-phenyl-1 ,3,4-thiadiazolo- [3,2-a] pyrimidine with Amin

“…The introduction of a substituent at position 6 of the1,3,4-thiadiazolo [3,2-a] pyrimidine system efficientlyenhances the physiological activity of the oleculef [8][9][10] .This replacement occurs in the reactions of 1,3,4 -thiadiazolo [3,2-a] pyrimidine derivatives withelectrophiles [11][12][13][14][15] . In the present work, we studied the possibilities of thesynthesis of various derivatives of 1,3,4-thiadiazolo [3,2 -a] pyrimidine.…”

Analysis of 2-R5-oxo 5H6-Ethylcorloxy late 7-Phenyl-1,3,4-thiadiazolo-(3,2,-a) pyrizmizdine with amine

“…The presentation of a substituent at position 6 of the 1,3,4-thiadiazolo [3, 2-a] pyrimidine framework effectively improves the physiological movement of the oleculef [8][9][10] . This substitution happens in the responses of 1,3,4-thiadiazolo [3,2-a] pyrimidine subsidiaries withelectrophiles [11][12][13][14][15] . In the present work, we examined the conceivable outcomes of the synthesie of different subordinates of 1,3,4-thiadiazolo [3,2-a] pyrimidine.…”

“…13 C NMR (100 MHZ, CDCI3, δ ppm):118 (C), 126,4 (CH), 128(CH), 128.7(CH), 128.7(CH), 136.9(C), 140 (C), 162,1(C), 163(C), 168(C), 172,6.…”