Synthesis and antimicrobial activity of novel 1,3,4‐oxadiazolyl‐quinazolin‐4(3H)ones

Abstract

magnified image A series of 1,3,4‐oxadiazolyl‐quinazolin‐4(3H)ones have been synthesized using known methods. All the compounds have been established on basis of elemental analysis, IR and NMR spectral data. The in vitro antimicrobial screening of the synthesized compounds were carried out against two gram‐positive bacteria (S. aureus, S. pyogenes), two gram‐negative bacteria (E. coli, P. aeruginosa), and three fungal species (C. albicans, A. niger, A. clavatus) using the broth microdilution method. The compounds 7d, 7g, 7l, 7o, 7p, and 7r possessed pronounced antibacterial activity whereas compound 7p exhibited promising antifungal activity. J. Heterocyclic Chem., (2010).