Synthesis and antimicrobial activity of new pyridine derivatives-I

Abstract

2-Amino substituted benzothiazoles 2a-l and 2-chloropyridine-3-carboxylic acid 3 were used to prepare 2-[N-(substitutedbenzothiazolyl)amino]pyridine-3-carboxylic acids (4a-l) in 2-ethoxy ethanol. Acid chlorides (5a-l) were condensed with 2-hydroxyethyl piperazine (6) and 2,3-dichloropiperazine (7) to prepare amide derivatives 2-[N-(substituted benzothiazolyl)amino]pyridin-3-yl (4-(2-hydroxyethyl)piperazin-1-yl)methanones (8a-l) and 2-[N-(substituted benzothiazolyl) amino]pyridin-3-yl(2,3-dichloropiperazine-1-yl)methanones (9a-l), respectively. The structures of new compounds have been established on the basis of elemental analysis and spectral (IR, 1 H NMR, and Mass spectra) studies. The in vitro antimicrobial activity was screened for all the synthesized compounds. Variable and modest activity were observed against the investigated strains of bacteria and fungi.

Facile synthesis, characterization and DFT calculations of 2-acetyl pyridine derivatives

“…1 Nitrogen containing heterocyclic compounds have anti-allergic, 2 antimicrobial, [3][4][5][6][7][8][9][10] anti-bacterial, anti-fungal, 11,12 anti-inflammatory, 13,14 and anti-cancer 15,16 activities. Many ligands derived from pyridine containing precursors are capable to couple with metals, the resulted complexes exhibit anti-tumor activities.…”

Potential Biosignificant Interest and Surface Activity of Efficient Heterocyclic Derivatives

“…IR spectra were recorded on a Pye Unicam SP-1000 cm 1 spectro-photometer using a KBr wafer technique at the Faculty of Science, Mansoura University. The 1 H NMR spectra were measured on a Bruker WP 300 MHz or a Bruker AC 300 spectrometer Fällanden, Switzerland operating at 400 MHz in DMSO-d 6 as a solvent, using TMS as an internal reference. Surface active property measurements of the prepared surfactants γ were made at 25 with a Du Nouy tensiometer Krüss Type 8451 , and biological activity was carried out in the Chemistry Department Faculty of Applied Science, Umm Al-Qura University, Saudi Arabia.…”

Synthesis and Heteroannulation of Pyridine and Related Heterocyclic Systems Having Surface and Biological Activities

“…A large number of heterocyclic compounds containing pyridine rings are associated with diverse pharmacological properties such as antimicrobial 15,16 , anticancer 17 anticonvulsant 18 , antiviral 19 , anti-HlV 20 , antifungal and antimycobacterial activities 21 . The pyridine heterocycle continues to play a vital role in the development of human medicines.…”