“…Among the new chemotypes, which also exhibited the highest levels of isoform selectivity, were the coumarins 27 , the sulfocoumarins [23][24][25][26] and their congeners, homosulfocoumarins (3H-1,2-benzoxathiepine 2,2dioxides) 31 , and saccharin derivatives [32][33][34] . Considering the fact that this last chemotype was somewhat chemically similar to hydantoin (imidazolidine-2,4-dione) that may serve as zinc binding group (ZBG) we investigated clinically used antibiotic Furagin (Figure 1), also known under names Furazidine, Furamags or Furazidin 35 , that contains hydantoin moiety, as well as newly prepared its derivatives.…”