Synthesis and Antimicrobial Activity of Bis-4,6-sulfonamidated 5,7-Dinitrobenzofuroxans

Abstract

A new series of bis-4,6-sulfonamidated 5,7-dinitrbenzofuroxans 7–11had been synthesized and tested for antimicrobial activity. The structures of new sulfanilamide derivatives were characterized by elemental analysis, IR spectroscopy, and mass spectrometry (MALDITOF). The synthesized compounds were tested for theirin vitroantimicrobial activity using the disk diffusion method against Gram-positive bacteriaStaphylococcus aureus; the Gram-negative bacteriaEscherichia coli, Pseudomonas aeruginosa, andProteus mirabilis; the fungal strainAspergillus niger; and the yeast-like pathogenic fungusCandida albicans. Our results indicate that the compounds7–11exhibit potent antimicrobial activity. The stability of the compounds was evaluated by TG and DSC methods.

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“…Irina V. Galkina et al, 29 studied new series of bis-4,6-sulfonamidated 5,7-dinitrobenzofuroxans and evaluated them for their antimicrobial activity. All the synthesized compounds were tested for their in vitro antimicrobial activity via the disk diffusion method against Gram +ve bacteria Staphylococcus aureus; the Gram-ve bacteria Escherichia coli, Pseudomonas aeruginosa, and Proteusmirabilis; Candida albicans, the yeast-like pathogenic fungus and the fungal strain Aspergillus niger.…”

Dyeing and Antibacterial Properties of Some Newly Synthesized Sulfonamide Reactive Dyes

“…Cotton fabrics finished with plant‐based dyes give antimicrobial activities, possibly as the dye plant extract contains some effective antimicrobial phytochemicals, for example, phenolics, terpenoids, alkaloids, essential oils, lectines, and polypeptides . On the other hand, the antimicrobial activities of synthetic dyes might probably be due to the presence of any specific group (s) and/or aromatic residue (s) in their chemical structure …”

“…[10] On the other hand, the antimicrobial activities of synthetic dyes might probably be due to the presence of any specific group (s) and/or aromatic residue (s) in their chemical structure. [14][15][16][17][18] The azo dye sulfonamides antibacterial drugs were the first impressive chemotherapeutic agents that could be used efficiently for the cure of bacterial infection in humans. [19] A series of azo dyes including the sulfonamide functional group was prepared as potential antimicrobial agents.…”

Polybenzimidazole-Triphenylphosphene-Catalyzed One-Pot Synthesis and Evaluation of Dihydropyridine Derivative as Antibiotics and Antifungals

“…Most of the researches have actively involved in the developing antimicrobial agents 1,4‐dihydropyridine derivatives (DHP) is more attractive drug components.…”