Synthesis and antimicrobial activity of some new pyrazole derivatives containing a ferrocene unit

Synthesis, characterization and antitumor activity of novel N-substituted α-amino acids containing ferrocenyl pyrazole-moiety

“…Our intentions were based on the synthetic combination of biomolecules with the known pharmacophores in order to avoid toxic or other unwanted side effects and prepare compounds with favorable properties for pharmacological applications. In continuation with our recent studies on ferrocene derivatives [24,25] we also report in this paper spectral characterization, electrochemical studies and test of their inhibitory effect on tumor growth in order to investigate the structure-reactivity relationship of this new antitumor class of compounds. …”

Synthesis and anti-bacterial activity of novel 1,3-pheylene-bis-N-acetyl- and N-phenylpyrazole derivatives

“…1 H and 13 C NMR spectra were recorded on a Bruker Avance DPX-400 instrument. As internal  (0.00) for standards served TMS 1 H NMR and CDCl 3 (77.0) for 13 C NMR spectra, J values are given in Hz.…”

“…[1][2][3][4][5][6][7][8] Addition, pyrazole derivatives play an important role in the development of pesticides and medicines. Several of pyrazole products are available and widely used as fungicides, antiviral agents, analgesic agents, insecticides and herbicides.…”

2-(5-Chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-6-(4-nitrophen­yl)-4-phenyl-1,3-diazabicyclo[3.1.0]hex-3-ene

“…Pyrazoles and their derivatives have been known to exhibit a wide range of physiological and pharmacological activities, such as anti-inflammatory [38], antibacterial [39,40], anti-convulsant [41], anticancer [42,43], anti-depressant [44], anti-hyperglycemic [45], antiviral [46], antipyretic [47], antioxidant [48], antitubercular [49], fungicides [50], and analgesic activities [51]. These heterocycles have also found applications in transition-metal chemistry as an analytical reagent [52], ligand used for complexation with metals and as antioxidant additives to fuels [53,54].…”