Synthesis and Antimicrobial Activities of Some Novel Quinoxalinone Derivatives

Abstract

Condensation of 4-benzoyl-1,2-phenylenediamine with sodium pyruvate in acetic acid furnished two products which were identified as 6-benzoyl and 7-benzoyl-3-methyl-2(1H)quinoxalinones (1a,b). Fusion of 1a with aromatic aldehydes furnished the styryl derivatives 2a-c. Alkylation of 1a,b with dimethyl sulphate or ethyl chloroacetate produced the N-alkyl derivatives 3a,b and 4a,b. Hydrazinolysis of the ester derivative 4a with hydrazine hydrate afforded the hydrazide derivative 5 which underwent condensation with aldehydes to give the corresponding hydrazone derivatives 6a,b. In addition, chlorination of 1a with thionyl chloride afforded the 2-chloro derivative 7 which was subjected to reaction with sodium azide and n-butylamine to yield the corresponding tetrazolo (8) and n-butylamino (9) derivatives, respectively. The structures of the compounds prepared were confirmed by analytical and spectral data. Also, some of the synthesized compounds were screened for antimicrobial activity.

Nano-kaoline/BF3/Fe3O4 Eco-friendly Nano-catalyst Promoted Synthesis of Quinoxalines Under Grinding Condition

“…These compounds inhibit the growth of gram-positive bacteria and are active against various transplantable tumors [9,10]. In addition, quinoxalines have biological activities such as antiviral [11], anticancer [12], antibacterial [13], antifungal [14], antidepressant [15], anti-HIV [16], and anti-in ammatory [17]. The best reported method without any additional puri cation.…”

Crystal structures of 3‐methyl‐2(1H)‐quinoxalinone and three substituted derivatives

“…Additionally, the quinoxalin-2-one ( Fig. 1) showed antimicrobial, [6][7][8] antifungic, [9] antiviral [10] and anticancer [11] activities. Methylquinoxalin-2(1 H)-one had recently been identified as corrosion inhibitor for mild steel in 1 M HCl solution.…”

Oxonium heterocyclic quinone in the synthesis of some cyanine dyes and their antimicrobial activity

“…Cyanine dyes are colorant compounds used in staining of internal limiting membrane (ILM) [18] and used as fluorescent dyes in DNA detection [19][20][21][22][23]. Quinone derivatives are widely used as fungicides [24,25], and antibacterial agent [25][26][27][28][29]. This paper reports the synthesis and characterization of a series of new monomethine, trimethine and styrylmethine cyanine dyes, and also their structure-property relationship of these dyes from their visible absorption spectra.…”