Synthesis and antimicrobial activities of some (E)-N'-1-(substituted benzylidene)benzohydrazides

Abstract

About ten substituted (E)-N-1-(substituted benzylidene) benzohydrazides have been synthesized. They are analyzed by their analytical, ultra violet (UV), Fourier transform-IR (FT-IR) and nuclear magnetic resonance (NMR) spectral data and evaluated by antimicrobial activities such antibacterial and antifungal activities.

Synthesis of promising antimicrobial agents: hydrazide‐hydrazones of 5‐nitrofuran‐2‐carboxylic acid

“…A significant part among thousands of new biologically active compounds synthesized each year by medicinal chemists around the world belongs to the group of hydrazide‐hydrazones (Bala, Uppal, Kajal, Kamboj, & Sharma, ; Popiołek, ; Rollas & Küçükgüzel, ). This is due to the fact that this group of compounds possesses very interesting and broad spectrum of biological properties (Bala et al, ; Popiołek, ; Rollas & Küçükgüzel, ), which include antimicrobial (Backes, Neumann, & Jursic, ; Manikandan et al, ; Metwally, Abdel‐Aziz, Lashine, Husseiny, & Badawy, ; Rollas, Gulerman, & Erdeniz, ; Zha et al, ), anticancer (Kumar, Kumar, Ghosh, & Shah, ; Nasr et al, ; Nasr, Bondock, & Youns, ; Nikolova‐Mladenova, Momekov, Ivanov, & Bakalova, ; Sreenivasulu, Reddy, Sujitha, Kumar, & Raju, ; Tantak et al, ), anti‐inflammatory (Gökçe, Utku, & Küpeli, ; Moldovan et al, ; Sondhi, Dinodia, & Kumar, ), anticonvulsant (Dehestani et al, ) and analgesic activity (Navidpour, Shafaroodi, Saeedi‐Motahar, & Shafiee, ).…”

Updated Information on Antimicrobial Activity of Hydrazide–Hydrazones

“…Their activity against tested fungi was higher or equal to the activity of Amphotericin B (Table 14) [15]. Analysis of the diameter of zone of inhibition growth (mm) of compounds obtained by Manikandan et al revealed that only hydrazide-hydrazone 42 had shown good antifungal sensitivity against three species of fungi (Figure 33, Table 15) [16]. Nitrofurazone analogues synthesized by Popiołek and Biernasiuk also showed interesting antifungal activity.…”

“…Hydrazidehydrazones 5 and 6 showed no cytotoxic activity at 0-500 µg/mL concentrations [15]. Analysis of the values of the zone of inhibition growth of compounds synthesized by Manikandan et al revealed that among obtained hydrazide-hydrazones, only derivative with 4-fluorophenyl substituent 7 had shown satisfactory antibacterial sensitivity in comparison with ciprofloxacin (Figure 5, Table 3) [16]. The results of the study by Popiołek and Biernasiuk indicated that synthesized and in vitro examined hydrazide-hydrazones exhibited a wide spectrum of antibacterial activity against tested reference bacteria.…”

“…Due to this, searching for novel effective and non-toxic antifungal agents is necessary [43,44]. Many hydrazide-hydrazones beside antibacterial activity also possess interesting antifungal properties [14][15][16][17][18][19]21,23,26,29,45,46]. Krátký et al evaluated hydrazide-hydrazones of 4-trifluoromethylbenzoic acid also as possible antifungal agents.…”

Synthesis and Antiviral Properties against SARS-CoV-2 of Epoxybenzooxocino[4,3-b]Pyridine Derivatives

“…Since the carbonyl group readily reacts with N-nucleophiles, we have taken this route of addition of aroylhydrazones. The latter were chosen primarily as additional pharmacophores, since aroylhydrazones are widely used in medicine as broad-spectrum bactericides [13][14][15] and anti-tuberculosis drugs [16][17][18]. Other examples of medical applications of these compounds are as anti-inflammatory [19] and antidepressant agents [20].…”