Synthesis and Antimalarial Activity of Substituted Pyrazole Derivatives.

Abstract

Synthesis and Antimalarial Activity of Substituted Pyrazole Derivatives. -A variety of arylaminopyrazoles (IV) (8 examples) are synthesized and evaluated for their antimalarial activity. Ester derivatives (IVa) and (IVb) prove to be potent antimalarial drugs. -(DOMINGUEZ, JOSE N.; CHARRIS, JAIME E.; CAPARELLI, MARIO; RIGGIONE, FLAVIA; Arzneim.-Forsch. 52 (2002) 6, 482-488; Lab. Sint. Org., Fac. Farm., Univ. Cent. Venezuela, Caracas 1051, Venez.; EN)