Synthesis and antileukemic activity of an ursolic acid derivative: A potential co-drug in combination with imatinib

Silva, Elenilson Figueiredo da; Vargas, Artur S. de; Willig, Júlia Biz; Oliveira, Cristiane Bernardes de; Zimmer, Aline Rigon; Pilger, Diogo André; Buffon, Andréia; Gnoatto, Simone Cristina Baggio

doi:10.1016/j.cbi.2021.109535

Cited by 7 publications

(3 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It should be stressed here that oxime derivatives of betulonic acid and platanic acid have been studied earlier by other authors. However, with exception of the structures identical to compounds 3 , 15 and 19 that have been prepared before, 39,41–43 all other compounds of the prepared series of oxime derivatives of betulonic acid and platanic acid are new compounds. None of the synthesized compounds showed high cytotoxicity.…”

Section: Discussionmentioning

confidence: 96%

Oxime derivatives of betulonic acid and platanic acid as novel cytotoxic or antiviral agents

Černá,

Bildziukevich,

Rárová

et al. 2024

React. Chem. Eng.

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 96%

Oxime derivatives of betulonic acid and platanic acid as novel cytotoxic or antiviral agents

Černá,

Bildziukevich,

Rárová

et al. 2024

React. Chem. Eng.

View full text Add to dashboard Cite

show abstract

“…The mechanism of anticancer activities of 2c was studied and the results showed that the 2c derivative induces apoptosis through caspase 3, and 8; and causes cell cycle arrest. Furthermore, the synergistic effects of 2c and imatinib, which is a standard kinase inhibitor, was found when used in combination [ 52 ].…”

Section: Introductionmentioning

confidence: 99%

Ursolic acid: a natural modulator of signaling networks in different cancers

et al. 2022

View full text Add to dashboard Cite

Incidence rate of cancer is estimated to increase by 40% in 2030. Furthermore, the development of resistance against currently available treatment strategies has contributed to the cancer-associated mortality. Scientists are now looking for the solutions that could help prevent the disease occurrence and could provide a pain-free treatment alternative for cancers. Therefore, efforts are now put to find a potent natural compound that could sever this purpose. Ursolic acid (UA), a triterpene acid, has potential to inhibit the tumor progression and induce sensitization to conventional treatment drugs has been documented. Though, UA is a hydrophobic compound therefore it is usually chemically modified to increase its bioavailability prior to administration. However, a thorough literature indicating its mechanism of action and limitations for its use at clinical level was not reviewed. Therefore, the current study was designed to highlight the potential mechanism of UA, its anti-cancer properties, and potential applications as therapeutic compound. This endeavour is a valuable contribution in understanding the hurdles preventing the translation of its potential at clinical level and provides foundations to design new studies that could help enhance its bioavailability and anti-cancer potential for various cancers.

show abstract

“…Ursolic acid (3-hydroxy-12-ursen-28-oic acid, UA, Figure 1) belongs to pentacyclic triterpenoids that mainly exist in plants such as the whole grass of Prunella vulgaris, and Ilex. It exhibits wide range of pharmacological activities, including anti-oxidation (Wang et al, 2018), anti-bacterial (Qian et al, 2020), anti-ulcer (Liu et al, 2016), anti-inflammatory (Wang et al, 2018), anti-tumor (Cao et al, 2020) anti leukemia (da Silva et al, 2021), lowering blood glucose (Alkreathy & Ahmad, 2020), as well as obvious stability and cooling effects on the central nervous system (Colla et al, 2021), and liver protection (Ma et al, 2021). In recent years, it has attracted much attention due to its strong pharmacological activity, slight side effects, and a vast range of sources.…”

mentioning

confidence: 99%

Recent progress in the development of ursolic acid derivatives as anti‐diabetes and anti‐cardiovascular agents

Dai,

Sun,

Tan

et al. 2023

Chem Biol Drug Des

View full text Add to dashboard Cite

Ursolic acid (UA) is a pentacyclic triterpenoid, which exhibits many biological activities, particularly in anti‐cardiovascular and anti‐diabetes. The further application of UA is greatly limited due to its low bioavailability and poor water solubility. Up to date, various UA derivatives have been designed to overcome these shortcomings. In this paper, the authors reviewed the development of UA derivatives as the anti‐diabetes anti‐cardiovascular reagents.

show abstract

Synthesis and antileukemic activity of an ursolic acid derivative: A potential co-drug in combination with imatinib

Cited by 7 publications

References 22 publications

Oxime derivatives of betulonic acid and platanic acid as novel cytotoxic or antiviral agents

Oxime derivatives of betulonic acid and platanic acid as novel cytotoxic or antiviral agents

Ursolic acid: a natural modulator of signaling networks in different cancers

Recent progress in the development of ursolic acid derivatives as anti‐diabetes and anti‐cardiovascular agents

Contact Info

Product

Resources

About