Synthesis and Antihypoxic Activity of New Diphenylguanidine Derivatives

Trukhanova, Yulia A.; Spiridonova, Dar’ya V.; Yuskovets, Valery N.; Yakovlev, I. P.; Kuvaeva, Elena V.; Ivkin, D. Yu.; Semakova, T. L.

doi:10.2139/ssrn.4149698

Search citation statements

Order By: Relevance

Paper Sections

Select...

Introduction1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2023

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(1 citation statement)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the literature, you can find a fairly large number of publications on methods for obtaining N ‐substituted glutarimide derivatives [7] …”

Section: Introductionmentioning

confidence: 99%

Facile Directed Synthesis of (Z)‐1‐(Aryl(arylimino)methyl)piperidine‐2,6‐diones from C,N‐Diarylformamidines

et al. 2023

View full text Add to dashboard Cite

A simple methodology has been developed for the synthesis of previously unstudied N‐substituted glutarimide derivatives ‐ (Z)‐1‐(aryl(arylimino)methyl)piperidine‐2,6‐diones 4 a–p obtained in one step from C,N‐diarylformamidines 1 a–p and glutaric anhydride 6 with product yields from 46 up to 88 % and chromatographic purity from 94 to 99 %. The structures of the obtained compounds were proved using NMR spectroscopy 1H, 13C, X‐ray diffraction analysis, mass spectroscopy, and elemental analysis. An in vivo study of the analgesic activity of a representative of series 4 a was carried out.

show abstract

“…In the literature, you can find a fairly large number of publications on methods for obtaining N ‐substituted glutarimide derivatives [7] …”

Section: Introductionmentioning

confidence: 99%