Synthesis and antihypertensive activity of 2-sulfonamido- and 2-sulfamido-1,3,4,6,7,11b.alpha.-hexahydro-2H-benzo[a]quinolizines

Abstract

°All compounds exhibited IR and NMR spectra consistent with the assigned structure.b There were four rats per group in each experiment. c Yield of analytically pure material; yields were not optimized. d C, H, and N analyses were within ±0.4% of theoretical values for the formulas given. ® Means ± SE; all results were analyzed for statistically significant differences from control values using analysis of variance; nonsignificant values (p > 0.05) are indicated by an asterisk, f Decomposition. g Toxic at 50 mg/kg.

Difluorinated Danishefsky's Diene: A Versatile C4 Building Block for the Fluorinated Six-Membered Rings

“…The reaction of cyclic imine 5e afforded the mono-fluorinated cycloadduct 6e in 52% yield by a sequence of the cycloaddition followed by dehydrofluorination of the corresponding difluorinated cycloadduct (entry 5). The arylquinolizine ring system is common in many naturally occurring alkaloids. , The interesting biological activities of many of these compounds and their derivatives have promoted considerable effort directed toward the construction of this system 2 Lewis Acid Catalyzed Hetero Diels−Alder Reactions of 2b with Imines a Isolated yields from α,β-unsaturated ketone 3b . …”