Synthesis and Antifungal Activity of 3′-Deoxyribonucleosides

Synthesis of New 3′-Deoxyribonucleosides Employing the Acid-Catalyzed Fusion Method

“…In particular, on the basis that 3'-deoxyribonucleosides exhibit a number of biological activites, e.g., antifungal, antibacterial, antiparasitic, and anticancer activity [9], and a high affinity for adenotin [10][11], we coupled 2,6-dichloro-3-deazapurine (1) with the 3-deoxyribose derivative 2 to obtain compounds of the general formula II.…”

Conformational Rigidity Introduced by 2′,5′-Phosphodiester Links in Dna

“…3 0 -Deoxyribonucleotides were synthesized by using published procedure 26 . Protected 3 0 -deoxyriboncleoside-phosphoramidites and CPG loaded 3 0 -deoxyribonucleosides were prepared by following procedure.…”

Evaluation of himachalol in murine invasive aspergillosis*

“…Himachalol and saperconazole (SCZ) (Recordati SPA) were dissolved in dimethylsulphoxide (DMSO) to obtain stock solutions of 10 mg ml-I and 1 mg ml-I respectively. The in vitro activity of the product(s) was determined by the macrobroth twofold serial dilution (TFSD) and microbroth microtitre (MT) technique(s) [4]. For TFSD, the product(s) were diluted in Sabouraud glucose broth (pH 5.6) containing Aspergillus fumigatus conidio spores ( lo4 cells ml-').…”