Synthesis and antifungal activity of (Z)-5-arylidenerhodanines

Sortino, Maximiliano; Delgado, Paula; Juárez, Sabina; Quiroga, Jairo; Abonı́a, Rodrigo; Insuasty, Braulio; Nogueras, Manuel; Rodero, L; Garibotto, Francisco Matías; Enriz, Ricardo D.; Zacchino, Susana

doi:10.1016/j.bmc.2006.09.038

Cited by 186 publications

(112 citation statements)

References 43 publications

(60 reference statements)

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“…To evaluate the antifungal potential, concentrations of peptides up to 200 mM were incorporated in the growth media according to previously reported procedures [11,24,25]. Compounds producing no inhibition of fungal growth at 200 mM were considered inactive.…”

Section: Antifungal Activitymentioning

confidence: 99%

Penetratin and derivatives acting as antifungal agents

Masman

Rodrı́guez

Raimondi

et al. 2009

European Journal of Medicinal Chemistry

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The synthesis, in vitro evaluation, and conformational study of RQIKIWFQNRRMKWKKeNH 2 (penetratin) and related derivatives acting as antifungal agents are reported. Penetratin and some of its derivatives displayed antifungal activity against the human opportunistic pathogenic standardized ATCC strains Candida albicans and Cryptococcus neoformans as well as clinical isolates of C. neoformans. Among the compounds tested, penetratin along with the nonapeptide RKWRRKWKKeNH 2 and the tetrapeptide RQKKeNH 2 exhibited significant antifungal activities against the Cryptococcus species. A comprehensive conformational analysis on the peptides reported here using three different approaches, molecular mechanics, simulated annealing and molecular dynamics simulations, was carried out. The experimental and theoretical results allow us to identify a topographical template which may provide a guide for the design of new compounds with antifungal characteristics against C. neoformans.

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Section: Antifungal Activitymentioning

confidence: 99%

Penetratin and derivatives acting as antifungal agents

Masman

Rodrı́guez

Raimondi

et al. 2009

European Journal of Medicinal Chemistry

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“…The rhodanine derivatives of 3-alkilocarboxylic acids have been exhibited pharmaceutical targets. Their antiin ammatory, antifungal, antituberculous, antibacterial, antiviral, and anticancer potentials have been reported [1][2][3][4][5][6][7][8][9][10]. The title compound was synthesized via reaction of corresponding amino acid, chloroacetic acid and carbon disulphide [11].…”

Section: Discussionmentioning

confidence: 99%

Crystal structure of 2-(4-oxo-2-thioxothiazolidin-3-yl)acetic acid monohydrate, C₅H₇NO₄S₂

Barakat

Ali

Al‐Majid

et al. 2016

Zeitschrift Für Kristallographie - New Crystal Structures

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“…Chalcone is one of the major classes of natural products. It possess several biological activities such as antibacterial [1][2] , anti-fungal [3][4] and anti-tumour activities [5][6] . The pyrimidine derivatives are also known to exhibit diverse pharmacological properties such as effective bactericides and fungicides 7 .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Spectral Characterization and Antimicrobial Activities of Ethyl-2-(4-(naphthalene-1-yl)-6-phenyl- pyrimidin-2-yl amino)acetate Derivatives

2017

Chem Sci Trans

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Abstract:The novel series of ethyl-2-(4-naphthalene-1-yl)-6-phenyl pyrimidin-2-yl amino)acetate derivatives were synthesised by the condensation reactions of 4-(naphthalene-1-yl)-6-phenyl pyrimidin-2-amines reacted with chloroethyl acetate and K 2 CO 3 as a catalyst. The 4-(naphthalene-1-yl)-6-phenyl pyrimidin-2-amines were occurred by the reaction between naphthalene chalcones and guanidine nitrate in the presence of ethanolic sodium hydroxide solution. The naphthalene chalcones were synthesised from substituted aldehydes treated with 1-acetyl naphthalene. Finally the synthesised compounds were determined by elemental analysis and spectral characterizations such as FT-IR, 1 H NMR and 13 C NMR. The antimicrobial activities of the new synthesised heterocyclic compound are evaluated against gram positive, gram negative bacterial and fungal strains. The electron withdrawing chloro substituted derivative have an excellent zone of inhibition against bacterial strains.

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Synthesis and antifungal activity of (Z)-5-arylidenerhodanines

Cited by 186 publications

References 43 publications

Penetratin and derivatives acting as antifungal agents

Penetratin and derivatives acting as antifungal agents

Crystal structure of 2-(4-oxo-2-thioxothiazolidin-3-yl)acetic acid monohydrate, C₅H₇NO₄S₂

Synthesis, Spectral Characterization and Antimicrobial Activities of Ethyl-2-(4-(naphthalene-1-yl)-6-phenyl- pyrimidin-2-yl amino)acetate Derivatives

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Synthesis and antifungal activity of (Z)-5-arylidenerhodanines

Cited by 186 publications

References 43 publications

Penetratin and derivatives acting as antifungal agents

Penetratin and derivatives acting as antifungal agents

Crystal structure of 2-(4-oxo-2-thioxothiazolidin-3-yl)acetic acid monohydrate, C5H7NO4S2

Synthesis, Spectral Characterization and Antimicrobial Activities of Ethyl-2-(4-(naphthalene-1-yl)-6-phenyl- pyrimidin-2-yl amino)acetate Derivatives

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Crystal structure of 2-(4-oxo-2-thioxothiazolidin-3-yl)acetic acid monohydrate, C₅H₇NO₄S₂