Synthesis and antifungal activity of novel α-alkoxyimino-(1H-benzoimidazol-2-yl)acetonitriles containing piperazine moiety

Jin, Qingdong; Li, Fubo; Liu, Ying; Jin, Fengxiang; Jiang, Lin

doi:10.1007/s11164-014-1853-9

Cited by 4 publications

(2 citation statements)

References 15 publications

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“…Benzimidazole is a popular nucleus in structural manipulation in medicinal chemistry and has been intensively discussed in the literature [ 19 , 21 , 22 , 23 , 24 ] and many benzimidazoles are reported to show anthelmintic [ 25 , 26 ], antimicrobial [ 27 , 28 , 29 , 30 , 31 , 32 ], anti-HIV [ 33 , 34 , 35 ], antiviral [ 36 , 37 ], anti-inflammatory [ 38 , 39 ], anticancer [ 40 , 41 , 42 , 43 , 44 ], anticonvulsant [ 45 ], antidiabetic [ 45 , 46 ], antihypertensive [ 47 ], anti-tuberculosis [ 48 , 49 ], antimalarial [ 50 , 51 ] and antioxidant [ 52 , 53 ] activities.…”

Section: Benzazolesmentioning

confidence: 99%

Importance of Fluorine in Benzazole Compounds

2020

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Fluorine-containing heterocycles continue to receive considerable attention due to their unique properties. In medicinal chemistry, the incorporation of fluorine in small molecules imparts a significant enhancement their biological activities compared to non-fluorinated molecules. In this short review, we will highlight the importance of incorporating fluorine as a basic appendage in benzothiazole and benzimidazole skeletons. The chemistry and pharmacological activities of heterocycles containing fluorine during the past years are compiled and discussed.

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Section: Benzazolesmentioning

confidence: 99%

Importance of Fluorine in Benzazole Compounds

2020

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“…As part of their efforts in synthesizing benzimidazole and alkoxyamine derivatives for antifungal activities, Jin et al and his team have investigated the effect of appendage piperazine moiety on a series of α-alkoxyimino-(1H-benzoimidazol-2-yl) acetonitriles. The derivatives (24 and 25) showed high antifungal activities against B. cinerea with EC50 7.14 and 13.99 μg/mL respectively, which is more potent than the standard used in their investigation [64].…”

Section: Benzimidazoles Containing Piperazinementioning

confidence: 95%

The Impact of Incorporation Piperazine on Biological Activities of Benzazoles

Al-Harthy,

Zoghaib,

Abdel-Jalil

2024

Heterocyclic Chemistry - New Perspectives [Working Title]

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Heterocycles are widely distributed compounds in natural products and are involved in many biological processes. Its uses have been extended to different fields, including industry, medicine, and agriculture sectors. Benzazole is one of the popular heterocycle scaffolds known as a privilege structure which is commonly found in many pharmaceutical agents. Another outstanding scaffold is piperazine that is known as a distinguishable motif in drug design with a wide range of biological activities. One of the fruitful approaches in the drug design is a hybridization of privilege structures in one skeleton which are believed to grant a characteristic feature with improved or more selective biological activities than the two scaffolds. The effect that piperazine imparted while introduced into a benzazole has drawn attention since first used in the nineteenth century. Numerous research has been performed discussing the synthesis and biological activities of benzazoles containing piperazine. In this chapter, we will highlight a general introduction about chemistry and structure of piperazine, and its importance in medicinal chemistry and benzazole as well. Next, several studies will be discussed that highlight the importance of incorporating piperazine in benzazole skeletons, benzimidazole, benzothiazole, and benzoxazole, and biological activity inherited from this combination.

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Synthesis, bioactivity and computational simulation study of novel (Z)-3-caren-5-one oxime ethers as potential antifungal agents

Kang

Huang

et al. 2022

Res Chem Intermed

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Synthesis and antifungal activity of novel α-alkoxyimino-(1H-benzoimidazol-2-yl)acetonitriles containing piperazine moiety

Cited by 4 publications

References 15 publications

Importance of Fluorine in Benzazole Compounds

Importance of Fluorine in Benzazole Compounds

The Impact of Incorporation Piperazine on Biological Activities of Benzazoles

Synthesis, bioactivity and computational simulation study of novel (Z)-3-caren-5-one oxime ethers as potential antifungal agents

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