Synthesis and Antifungal Activity of Some 6H-thiochromeno[4,3-b]quinolines

Wang, Ge; Yang, Gengliang; Ma, Zhengyue; Tian, Wei; Fang, Baoling; Li, Linbo

doi:10.5539/ijc.v2n1p19

Cited by 3 publications

(2 citation statements)

References 15 publications

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“…The antifungal activity depends on the substituent of the aryl group attached to the thiochromeno ring, as well as the evaluated species. In general, these compounds seem to be less susceptible against Candida sp., and the presence of a nitro group at position 6 was favorable for the activity against Candida glabrata …”

Section: Structural Changes At the 8hq Core Based On The Microorganis...mentioning

confidence: 99%

“…In general, these compounds seem to be less susceptible against Candida sp., and the presence of a nitro group at position 6 was favorable for the activity against Candida glabrata. 115 Figure 30 presents the main highlights of the SAR of 8HQs with fused cycles. Series 28a−j (Figure 28) presented modest antibacterial activity, in general.…”

Section: ■ Introductionmentioning

confidence: 99%

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Novel Antimicrobial 8-Hydroxyquinoline-Based Agents: Current Development, Structure–Activity Relationships, and Perspectives

et al. 2021

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The search for new antimicrobials is imperative due to the emergent resistance of new microorganism strains. In this context, revisiting known classes like 8-hydroxyquinolines could be an interesting strategy to discover new agents. The 8-hydroxyquinoline derivatives nitroxoline and clioquinol are used to treat microbial infections; however, these drugs are underused, being available in few countries or limited to topical use. After years of few advances, in the last two decades, the potent activity of clioquinol and nitroxoline against several targets and the privileged structure of 8-hydroxyquinoline nucleus have prompted an increased interest in the design of novel antimicrobial, anticancer, and anti-Alzheimer agents based on this class. Herein, we discuss the current development and antimicrobial structure–activity relationships of this class in the perspective of using the 8-hydroxyquinoline nucleus for the search for novel antimicrobial agents. Furthermore, the most investigated molecular targets concerning 8-hydroxyquinoline derivatives are explored in the final section.

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Section: Structural Changes At the 8hq Core Based On The Microorganis...mentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Novel Antimicrobial 8-Hydroxyquinoline-Based Agents: Current Development, Structure–Activity Relationships, and Perspectives

et al. 2021

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Design, Synthesis, andIn SilicoMolecular Docking Study of Some Novel Thiochromene Derivatives with Antimicrobial Potential

Elkanzi

Azab

Bakr

2022

Polycyclic Aromatic Compounds

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Design, Synthesis and Antifungal Activity of 3-substituedmethylenethiochroman-4-one Derivatives

Zhang¹,

Ma²,

Yang³

et al. 2011

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Four new 3-substituedmethylenethiochroman-4-one derivatives were prepared from (z)-3-(chlorome- thylene)thiochroman-4-one. They were characterized by analytical and spectral methods. In vitro antifungal activities of these synthesized compounds were evaluated against ten species of fungi, and the results showed that (e)-3-chloromethylene compound exhibited a similar good activity against fungi to (z)-3-chloromethylene compound. (Z)-3-substituedaminomethylene compound also exhibited antifungi activity to some extent.

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Synthesis and Antifungal Activity of Some 6H-thiochromeno[4,3-b]quinolines

Cited by 3 publications

References 15 publications

Novel Antimicrobial 8-Hydroxyquinoline-Based Agents: Current Development, Structure–Activity Relationships, and Perspectives

Novel Antimicrobial 8-Hydroxyquinoline-Based Agents: Current Development, Structure–Activity Relationships, and Perspectives

Design, Synthesis, andIn SilicoMolecular Docking Study of Some Novel Thiochromene Derivatives with Antimicrobial Potential

Design, Synthesis and Antifungal Activity of 3-substituedmethylenethiochroman-4-one Derivatives

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