Synthesis and anticonvulsant activity of some potential thiazolidinonyl 2-oxo/thiobarbituric acids

Benzothiazole Incorporated Barbituric Acid Derivatives: Synthesis and Anticonvulsant Screening

“…Barbituric acid being an essential component of the current antiepileptic drugs phenobarbital and mephobarbital ( Fig. 1) has been exploited previously [3,4] to get newer anticonvulsant agents that are better anticonvulsants in terms of efficacy and safety.…”

Progress in the chemistry of 4‐ thiazolidinones

“…4-Thiazolidinone derivatives 14 were obtained by refluxing equimolecular amounts of aldimines 13 and thioglycolic acid in dry benzene [45][46][47][48][49][50], or in anhydrous ZnCl 2 [51].…”

Synthesis of bis-thiazolidin-4-ones from N,N,N″-(1,ω-alkanediyl)bis(N″-organylthiourea) derivatives

“…The 4-thiazolidinone ring system comprises a large number of biologically active compounds that have been evaluated for their anticonvulsant [7,8], antidiarrheal [9], antiplatelet activating [10], antimicrobial [3,10,11], anti-HIV [12][13][14][15], and anticancer [16][17][18] activities. Several methods for the stereoselective synthesis of thiazolidin-4-ones are available in the literature [19][20][21][22][23][24][25][26][27][28][29].…”