Synthesis and anticonvulsant activity of 6,7,8,9-tetra hydro-5H-5-(2′-hydroxy phenyl)-2-(4′-substituted benzylidine)-3-(4-nitrophenyl amino) thiazolo quinazoline derivatives

Synthesis of new functionalized thiazolo pyridine-fused and thiazolo pyridopyrimidine-fused spirooxindoles via one-pot reactions

“…General interest in spiro thiazole-based heterocycles structures comes not only from their structural properties but also from their biological applications, so introducing new synthetic procedures for the synthesis of spiro thiazole-based heterocycles has been an active field of chemical research for well over a century and would be beneficial to develop new therapeutic agents [21,22,23]. In continuation of our work on the expansion of new methods to construct potential biologically active heterocycles [24,25,26] and considering typical substituent impacts on bioactive properties, we herein report new synthetic approaches to sulfur-containing spiro heterocycle molecules.…”