Synthesis and Anticonvulsant Activity of O-alkylated Derivatives of 1-(2-naphthyl)-2-(imidazol-1-yl)ethanone Oxime

Bansal, Ranju; Chauhan, Prem M. S.; Sharma, Raj Pal

doi:10.1055/s-0032-1316377

Cited by 3 publications

(2 citation statements)

References 7 publications

(9 reference statements)

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“…It contains a six-membered ring with two adjacent nitrogen atoms, and is aromatic [150]. Pyridazine derivatives have various biological applications [152][153][154][155].…”

Section: The Pyridazine Functional Groupmentioning

confidence: 99%

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Current Research on Antiepileptic Compounds

2015

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Epilepsy affects about 1% of the world's population. Due to the fact all antiepileptic drugs (AEDs) have some undesirable side effects and about 30% of epileptic patients are not seizure-free with the existing AEDs, there is still an urgent need for the development of more effective and safer AEDs. Based on our research work on antiepileptic compounds and other references in recent years, this review covers the reported work on antiepileptic compounds which are classified according to their structures. This review summarized 244 significant anticonvulsant compounds which are classified by functional groups according to the animal model data, although there are some limitations in the data. This review highlights the properties of new compounds endowed with promising antiepileptic properties, which may be proven to be more effective and selective, and possibly free of unwanted side effects. The reviewed compounds represent an interesting possibility to overcome refractory seizures and to reduce the percentage of patients with a poor response to drug therapy.

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“…It contains a six-membered ring with two adjacent nitrogen atoms, and is aromatic [150]. Pyridazine derivatives have various biological applications [152][153][154][155].…”

Section: The Pyridazine Functional Groupmentioning

confidence: 99%

“…Karakurt (Table 8) [151]. [150] 192 20 of oxime ether groups to the compounds as a small oxygen functional group had been studied. Meanwhile, oxime ether linkages also are used as a mechanism for pro-drug generation [147].…”

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confidence: 99%