Synthesis and Anticancer Research of <i>N</i>‐(2‐aminophenyl)benzamide Acridine Derivatives as Dual Topoisomerase I and Isoform‐Selective HDAC Inhibitors

Zhang, Bin; Zhang, Qiting; Liu, Zedong; Wang, Ning; Jin, Haixiao; Liu, Feng; Zhang, Cunlong; He, Shan

doi:10.1002/slct.202001880

Cited by 12 publications

(9 citation statements)

References 36 publications

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“…Additional mediators have been devised to increase the selectivity of the assay by lowering the overpotential and minimizing the oxidation of interfering species. The incorporation of platinum nanoparticles (Pt NPs) increases the sensitivity of glucose detection by favoring the selective oxidation of H 2 O 2 (Figure b) . Although Pt is highly reactive toward H 2 O 2 , the high reaction potential of the electrode remains a drawback.…”

Section: Principles Of Enzymatic Glucose Sensingmentioning

confidence: 99%

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Enzyme‐Based Glucose Sensor: From Invasive to Wearable Device

Lee

Hong

Baik

et al. 2018

Adv Healthcare Materials

577

396

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Blood glucose concentration is a key indicator of patients' health, particularly for symptoms associated with diabetes mellitus. Because of the large number of diabetic patients, many approaches for glucose measurement have been studied to enable continuous and accurate glucose level monitoring. Among them, electrochemical analysis is prominent because it is simple and quantitative. This technology has been incorporated into commercialized and research-level devices from simple test strips to wearable devices and implantable systems. Although directly monitoring blood glucose assures accurate information, the invasive needle-pinching step to collect blood often results in patients (particularly young patients) being reluctant to adopt the process. An implantable glucose sensor may avoid the burden of repeated blood collections, but it is quite invasive and requires periodic replacement of the sensor owing to biofouling and its short lifetime. Therefore, noninvasive methods to estimate blood glucose levels from tears, saliva, interstitial fluid (ISF), and sweat are currently being studied. This review discusses the evolution of enzyme-based electrochemical glucose sensors, including materials, device structures, fabrication processes, and system engineering. Furthermore, invasive and noninvasive blood glucose monitoring methods using various biofluids or blood are described, highlighting the recent progress in the development of enzyme-based glucose sensors and their integrated systems.

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Section: Principles Of Enzymatic Glucose Sensingmentioning

confidence: 99%

“…b) Effective gate voltage change (∆ V G eff ) versus H 2 O 2 concentrations ([H 2 O 2 ]) of the glucose sensor with or without platinum nanoparticles (Pt NPs) on graphene gate electrodes. Reproduced with permission . Copyright 2015, Nature Publishing Group.…”

Section: Principles Of Enzymatic Glucose Sensingmentioning

confidence: 99%

Enzyme‐Based Glucose Sensor: From Invasive to Wearable Device

Lee

Hong

Baik

et al. 2018

Adv Healthcare Materials

577

396

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“…The first graphene‐based FET was proposed by Ang et al . Since that time, several studies have used graphene‐based FETs in the field of biosensing, e. g. for the detection of DNA, RNA, glucose, dopamine (DA) and glutamate …”

Section: Introductionmentioning

confidence: 99%

Reduced‐Graphene‐Oxide‐Based Needle‐Type Field‐Effect Transistor for Dopamine Sensing

et al. 2020

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Owing to their intrinsic amplifying effect together with their temporal resolution, field‐effect transistors (FETs) are gaining momentum for the detection of different biomolecules at ultra‐low concentration levels such as, for example, neurotransmitters, particularly if the concentration level of the analyte is below the detection limit of commonly used electrochemical sensing methods. We demonstrate the fabrication of a spearhead reduced graphene oxide (rGO)‐based FET. The fabrication of the rGO‐based FET by means of an electrochemical pulse deposition technique enables a controllable process including both the deposition and reduction of the deposited graphene oxide between two carbon nanoelectrodes to form the channel of the rGO‐based FET. While using double‐barrel carbon nanoelectrodes, the as‐produced FETs offer new possibilities in terms of their applicability in very small volumes as well as the option of being positioned close to the desired measurement region. The fabrication process was evaluated and optimized to obtain rGO‐based FETs with high performance. The as‐fabricated devices were evaluated in terms of sensitivity and selectivity towards dopamine. The tested devices not only showed high sensitivity towards dopamine with a linear response ranging from 1 nM to 1 μM, but also maintained a similar sensing performance in the presence of 500 μM ascorbic acid.

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“…Since the basic principle was proposed, many approaches and electrodes with different architectures ranging from micro to nanostructured platforms have been demonstrated . On the other hand, the recent developments in the fabrication of miniaturized electronic devices have allowed for using graphene as an active component in in vitro glucose sensors as well as for glucose monitoring in blood ,. Lipani and co‐workers reported a strategy for hydrogel reservoir‐based glucose monitoring system in interstitial fluid.…”

Section: Miniaturized Bioelectronics On‐chipmentioning

confidence: 99%

Bioelectronics and Interfaces Using Monolayer Graphene

et al. 2018

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Graphene is expected to revolutionize several application areas ranging from portable energy conversion and storage to miniaturized biosensors for medical applications. In this endeavor, the control of surface characteristics is an essential aspect for understanding fundamental phenomena occurring at the graphene‐liquid interface. In this comprehensive review, we address recent progress in the investigation of the interfacial characteristics of monolayer graphene and methods for modulating the physical and chemical properties of this interface. We focus on the electrochemistry and field‐effect measurements in liquid, which provide an improved understanding of the unique graphene‐liquid interface, with due consideration of the influence of the underlying substrate and structural defects in graphene. Finally, we present reported examples of using single graphene monolayers in miniaturized devices for realizing sensors, neural interfaces and batteries.

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Synthesis and Anticancer Research of N‐(2‐aminophenyl)benzamide Acridine Derivatives as Dual Topoisomerase I and Isoform‐Selective HDAC Inhibitors

Cited by 12 publications

References 36 publications

Enzyme‐Based Glucose Sensor: From Invasive to Wearable Device

Enzyme‐Based Glucose Sensor: From Invasive to Wearable Device

Reduced‐Graphene‐Oxide‐Based Needle‐Type Field‐Effect Transistor for Dopamine Sensing

Bioelectronics and Interfaces Using Monolayer Graphene

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