Synthesis and anticancer evaluation of trinuclear N^N quinolyl-benzimidazole-based PGM complexes

Msimango, Nosipho; Welsh, Athi; Prince, Sharon; Smith, Gregory S.

doi:10.1016/j.inoche.2022.109840

Cited by 3 publications

(3 citation statements)

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“…The trinuclear ruthenium(II) arene complexes ( 1 – 3 ) were synthesized via two steps: (i) the reaction of the tris-2-quinolylbenzimidazole ligand ( L1 ), synthesized using procedures previously reported in the literature, 46 with either [Ru( p -cymene)Cl 2 ] 2 , [Ru(hexamethylbenzene)Cl 2 ] 2 or [Ru(benzene)Cl 2 ] 2 , and (ii) a salt metathesis reaction with ammonium hexafluorophosphate ( Scheme 1 ). All of the ruthenium(II) complexes were isolated as hexafluorophosphate salts in excellent yields (95–98%).…”

Section: Resultsmentioning

confidence: 99%

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Selective Targeting of Regulated Rhabdomyosarcoma Cells by Trinuclear Ruthenium(II)–Arene Complexes

Welsh,

Serala,

Prince

et al. 2024

J. Med. Chem.

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The use of benzimidazole-based trinuclear ruthenium-(II)−arene complexes (1−3) to selectively target the rare cancer rhabdomyosarcoma is reported. Preliminary cytotoxic evaluations of the ruthenium complexes in an eight-cancer cell line panel revealed enhanced, selective cytotoxicity toward rhabdomyosarcoma cells (RMS). The trinuclear complex 1 was noted to show superior shortand long-term cytotoxicity in RMS cell lines and enhanced selectivity relative to cisplatin. Remarkably, 1 inhibits the migration of metastatic RMS cells and maintains superior activity in a 3D multicellular spheroid model in comparison to that of the clinically used cisplatin. Mechanistic insights reveal that 1 effectively induces genomic DNA damage, initiates autophagy, and prompts the intrinsic and extrinsic apoptotic pathways in RMS cells. To the best of our knowledge, 1 is the first trinuclear ruthenium(II) arene complex to selectively kill RMS cells in 2D and 3D cell cultures.

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Section: Resultsmentioning

confidence: 99%

“…The tris(2-(2-(pyridin-2-yl)-1 H -benzo[ d ]imidazol-1-yl)ethyl)amine and tris(2-(2-(quinolin-2-yl)-1 H -benzo[ d ]imidazol-1-yl)ethyl)amine precursors and the tris(2-(2-(quinolin-2-yl)-1 H -benzo[ d ]imidazol-1-yl)ethyl)amine ( L1 ) ligand were synthesized using methods reported in the literature. , …”

Section: Methodsmentioning

confidence: 99%

Selective Targeting of Regulated Rhabdomyosarcoma Cells by Trinuclear Ruthenium(II)–Arene Complexes

Welsh,

Serala,

Prince

et al. 2024

J. Med. Chem.

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“…The second peak appeared at 315 nm (31746 cm -1 ) belongs to the electronegativity (π→π*) of the (C=C) bond in the benzimidazole and the aromatic ring, the third peak at 285 nm (35088 cm -1 ) belongs to the (n→π*) electron transfer of the hydroxyl phenol ring [14].…”

Section: Uv-vis Absorption Spectramentioning

confidence: 99%

Untitled

2023

J. Med. Chem. Sci.

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The production of the tridentate Azo ligand 2-[2/-(benzimidazolyl)azo]-4bromo-6-chloro phenol (BIABrClP) complexes using Co(III) and Ni(II) is discussed in this article. Spectral methods including 1 H-NMR, UV-Vis, FT-IR, magnetic moment measurements, molar conductance, and elemental analysis were used to thoroughly explore the coordination mode of azo ligand containing NNO donor atoms with metal ions. The octahedral geometry for the synthesized Ni(II) and Co(III) complexes was suggested from the analytical and spectral studies. According to in vitro assays for antibacterial activity, the majority of produced compounds exhibit good action against a variety of microorganisms, including Candida albicans, Staphylococcus aureus, and Escherichia coli.

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Trinuclear ruthenium(II) polypyridyl complexes: Evaluation as photosensitizers for enhanced cervical cancer treatment

Welsh,

Matshitse,

Khan

et al. 2024

Journal of Inorganic Biochemistry

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Synthesis and anticancer evaluation of trinuclear N^N quinolyl-benzimidazole-based PGM complexes

Cited by 3 publications

References 32 publications

Selective Targeting of Regulated Rhabdomyosarcoma Cells by Trinuclear Ruthenium(II)–Arene Complexes

Selective Targeting of Regulated Rhabdomyosarcoma Cells by Trinuclear Ruthenium(II)–Arene Complexes

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Trinuclear ruthenium(II) polypyridyl complexes: Evaluation as photosensitizers for enhanced cervical cancer treatment

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