Synthesis and anticancer evaluation of [d-Ala]-nocardiotide A
Rani Maharani,
Muhamad Imam Muhajir,
Jelang Muhammad Dirgantara
et al.
Abstract:We synthesized [d-Ala]-nocardiotide A as a derivative of nocardiotide A using a combination of solid phase peptide synthesis and liquid phase peptide synthesis to give the desired cyclic peptide product in a yield of 31% after purification.
“…7 A combination of solid-and solution-phase peptide synthesis is an effective strategy in the development of cyclopeptide compounds. [12][13][14] The linear peptide is synthesized in the solid phase and cyclized in the liquid phase with a very dilute concentration to prevent side reactions during the cyclization process. The synthesis of nodupetide and its analogues has not been reported previously.…”
[β-HIle]2-nodupetide is a nodupetide analogue, in which HMHA residue of nodupetide is replaced with β-HIle and it changes the ester to amide bond in the nodupetide's backbone.
“…7 A combination of solid-and solution-phase peptide synthesis is an effective strategy in the development of cyclopeptide compounds. [12][13][14] The linear peptide is synthesized in the solid phase and cyclized in the liquid phase with a very dilute concentration to prevent side reactions during the cyclization process. The synthesis of nodupetide and its analogues has not been reported previously.…”
[β-HIle]2-nodupetide is a nodupetide analogue, in which HMHA residue of nodupetide is replaced with β-HIle and it changes the ester to amide bond in the nodupetide's backbone.
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