Synthesis and anticancer evaluation of [d-Ala]-nocardiotide A

Abstract

We synthesized [d-Ala]-nocardiotide A as a derivative of nocardiotide A using a combination of solid phase peptide synthesis and liquid phase peptide synthesis to give the desired cyclic peptide product in a yield of 31% after purification.

Total synthesis of [β-HIle]2-nodupetide: effect of ester to amide substitution on its antimicrobial activity

“…7 A combination of solid-and solution-phase peptide synthesis is an effective strategy in the development of cyclopeptide compounds. [12][13][14] The linear peptide is synthesized in the solid phase and cyclized in the liquid phase with a very dilute concentration to prevent side reactions during the cyclization process. The synthesis of nodupetide and its analogues has not been reported previously.…”