Synthesis and anticancer activity of novel water soluble benzimidazole carbamates

Synthesis and biological evaluation of benzimidazole pendant cyanopyrimidine derivatives as anticancer agents

“…[6] In addition, the benzimidazole-substituted compounds possesses anti-fungal, antiviral, anthelmintic, antiproliferative, anti-hypertensive, H-3 antagonistic, human glucagon receptor antagonistic, male contraceptive and anti-infective activities. [6][7][8][9][10] Benzimidazole derivatives also exhibit significant cytotoxic activity towards leukemia, lung, prostate, melanoma, kidneys, breast and colon human cancer cell lines. [11][12][13][14][15][16] Yadav and group prepared a series of benzimidazole derivatives and determined their anticancer activity.…”

“…[17] In another study, Akhtar et al reported synthesis and anticancer potential of benzimidazole derivatives (2) targeting epidermal growth factor receptor (EGFR) inducing G2/M cell cycle arrest. [18] Cheong prepared [8] benzimidazole-oxetane derivatives and evaluated their anticancer activity. Compound 3, at 30 mg/kg dose inhibited tumor growth (T/C: 0.36) in a mouse model of the highly aggressive PC3MLN4 prostate cancer.…”

Synthesis and In Vitro Anticancer Evaluation of Some Benzimidazolium Salts

“…In another study, Cheong et al evaluated the anticancer activity of water soluble benzimidazole‐based organic compounds against the following three cancer cell lines: PC3MLN4, PC3, and A549. They reported that nearly all of the compounds exhibited low cytotoxicity against the cell lines.…”

Synthesis and antidiabetic evaluation of benzimidazole‐tethered 1,2,3‐triazoles

“…Benzimidazole can be considered as a privileged structure in medicinal chemistry, and its derivatives exhibit a variety of biological activities including antidiabetic activity. [8][9][10][11][12][13][14][15][16] Among different triazoles, 1,2,3triazoles particularly have a broad range of applications in the field of pharmaceutical and medicinal chemistry, and they are a part of many molecules reported as antidiabetic. [17][18][19][20][21][22][23][24] It has been reported that benzimidazole compounds, that is, 2-aryl benzimidazoles (A) and 2-(2chlorophenyl)-7-methyl-1H-benzo [d]imidazole (B), act as α-glucosidase inhibitors, [25][26][27] but there is still a need to discover some new analogs for improved inhibitory activity.…”