Synthesis and anticancer activity of a new water-soluble derivative of heptaplatin, cis-{Pt(II)[(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane](3-acetoxyl-cyclobutane-1,1-dicarboxylato)}

Abstract

A new water-soluble derivative of heptaplatin, cis-{Pt(II)[(4R,5R)-4,5bis(aminomethyl)-2-isopropyl-1,3-dioxolane](3-acetoxyl-cyclobutane-1,1-dicarboxylato)} has been synthesized, characterized by elemental analysis, MS, IR, and 1 H, 13 C NMR, and evaluated for in vitro anticancer activity in four human cancer cell lines. The stability of the derivative in water was also investigated by monitoring the changes of 1 H NMR in D 2 O. The results reveal that the new derivative has good solubility and stability in water and also shows high anticancer activity against gastric cancer cells, ovarian cancer cells, and colon cancer cells. Therefore, it is worthy of further evaluation for in vivo antitumor activity and toxicity.

In vitro and in silico evaluation of bioactivities and chemical composition of the aerial parts of Anchusa officinalis L. methanol extract

“…In this study, two major compounds were identified in the methanol lutein-glycoside, and rutin as distinctive components in A. officinalis L. 21 It is well known that cyclobutane derivatives have antioxidant, anticancer, [51][52][53][54] and antimicrobial activities. 55,56 Moreover, propyl gallate and tert-butyl-hydroquinone have antioxidants and anticancer activities.…”