Synthesis and anticancer activity of ruthenium half-sandwich complexes comprising combined metal centrochirality and planar chirality

In Vivo Enzymes Activities of Some Ru(II) Compounds with N-Alkylphenothiazines

“…Complex 2 caused a signifi cant decline in the activity of LDH 2 in all treated groups with signifi cant inhibition (p < 0.05) at doses of 4.5 μmol kg -1 (group III) and 90.4 μmol kg -1 (group IV) ( Table 2). A signifi cant increase (p < 0.05) was also observed in the activity of LDH 4 •-) and hydrogen peroxide (H 2 O 2 ) are constantly generated in aerobic organisms. Their low levels are vital for a number of cell signaling events and they are essential for proper cell function.…”

“…The complex (TF.2H)Ru(DMSO) 3 Cl 3 Cl·0.5C 2 H 5 OH (1) was prepared by the reaction of complex RuCl 2 (DMSO) 4  and trifl uoperazine dihydrochloride (TF.2HCl) in absolute ethanol [35]. In the reaction the starting complex RuCl 2 ( 6 -p-cymene) 2 with TF.2HCl in 2-propanol as solvent, complex 2 (TF.2H)RuCl 3 ( 6 -p-cymene) Cl·0.5C 3 H 7 OH·0.5H 2 O was synthesized [36].…”

“…LDH isoenzymes (LDH [1][2][3][4][5] ) were detected by vertical electrophoresis on non-denaturing 7% PAGE using a Tris-glycine buffer, following the methods described [39]. The isoenzymes bands were detected using lithium lactate as a substrate in the presence of cofactors NADH and tetrazolium blue.…”

“…Metal complexes of ruthenium have been for more than twenty years in the focus of many researches in chemistry [1][2][3][4] as well as in medicine [5,6]. Their properties can be altered by the choice of ligands, which means that complexes potentially have multiple applications.…”

“…Ruthenium complexes have a good cytotoxic effect and their possible applications as non-competitive inhibitors of LDH were reported [22,23]. Ru(II) complexes can decrease total levels of serum LDH and LDH 4 in tumor cells, as well as increase serum glutamate oxaloacetate transaminase (SGOT) activity, without toxic effects on the liver [23]. A relationship between the increase of acethylcholinesterase and apoptosis of tumor cells was also reported [24,25].…”