Synthesis and anticancer activity of novel NHC-gold(I)-sugar complexes

Synthesis of heterobimetallic gold(i) ferrocenyl-substituted 1,2,3-triazol-5-ylidene complexes as potential anticancer agents

“…2) were obtained from a solution of CDCl3 by slow evaporation. From the single crystal X-ray diffraction studies of 2, the Au-Ccarbene bond length was observed to be 1.981(3) Å, which is comparable both to the reported diarylated triazolylidene gold(I) chlorido Au-Ccarbene bond length (11); C38-C37-N6 102.16 (11). ; for 5: Au1-C1 2.045 (19); of 1.991(6) Å, 30 and to the ferrocenyl N1-alkylated triazolylidene gold(I) complex Au-Ccarbene bond length reported by Sarkar et al as 1.982(2) Å; 41 falling well within the range of other Au-Ccarbene bond lengths reported for N1-alkylated gold(I) trz chlorido complexes (1.980-1.993 Å).…”

“…5 Furthermore, the synergistic effect of two metal centers in a heterobimetallic complex would not only lead to enhanced activity but improve their stability and selectivity against cancer cells. 3 Although the anticancer properties of ferrocene ,6-10 gold(I) Nheterocyclic carbene (NHC) complexes [11][12][13][14] and heterobimetallic gold(I) complexes 3,5 are well known, heterobimetallic gold(I) carbene complexes bearing a metallocenyl derivative are less explored for this application. reported on the anticancer properties of cationic gold(I) ferrocenyl biscarbene and the triphenylphosphine complexes ( Fig.…”

Evaluating Ligand Modifications of the Titanocene and Auranofin Moieties for the Development of More Potent Anticancer Drugs

“…The patients received 3 mg AF orally twice per day for 28 days. Some patients reported experiencing diarrhea, nausea, vomiting, fatigue, thrombocytopenia, and thromboembolism, none of which exceeded grade 2 of To further study the role of the thioglucose ligand of the AF analogue, Dada et al studied the replacement of this ligand with other sugars that have been conjugated to anticancer drugs in order to take advantage of the GLUT-mediated cellular uptake, which could potentially lead to a heightened activity [110]. In addition to AF's β-thioglucose, the other sugar moieties they studied were α-thioglucose, galactose, lactose and also lactose with a three-carbon spacer between the sugar and the metal (Figure 17).…”

Glycoconjugated Metal Complexes as Cancer Diagnostic and Therapeutic Agents

“…The investigation of new N ‐heterocyclic carbenes (NHCs) ligands on sugar‐based gold(I) complexes was carried out by Zhu and co‐workers in 2018 [113] . In this work, four complexes with the general formula NHC−Au(I)−SR, in which NHC is the 1,3‐dibenzyl‐4,5‐diphenyl‐imidazole ligand and SR represents the thiosugar moiety, were designed and synthesized ( 133 – 137 , Figure 39).…”