Synthesis and Anticancer Activity of Some Novel Fused Nicotinonitrile Derivatives

Synthesis and In Vitro Anticancer Evaluation of Symmetrically Bridged 1,3‐thiazine Derivatives

“…More importantly, the distance between the two thiazine rings can be tailored though varying the number of methylene groups of the spacer units of the dialdehydes 1a–c . The bridged dialdehydes 1a–c , which provide the complementary carbons of the six 1,3‐thiazine rings, were prepared from the alkylation reactions of the 4‐hydroxy‐3‐methoxybenzaldehyde with dihaloalkanes according to the literature . Compounds 2a–e , which possess two nucleophilic terminals of amide and thiol functionalities, were obtained from the addition reactions of the cyanoacetamide with the corresponding aryl or cyclohexyl isothiocyanates according to the literature .…”

Recent Progress on Nicotinonitrile Scaffold‐based Anticancer, Antitumor, and Antimicrobial Agents: A Literature Review

“…The newly synthesized compounds have low anticancer activity against SF‐268, MCF‐7, and NCI‐H460 cell lines. Compound 79 has the higher activity among the other compounds (Scheme ) .…”

“…Furthermore, reaction of pyridone 75 with α,β‐unsaturated carbonyl compounds 82 and 83 and benzoyl isothiocyanate gave the corresponding pyridine derivatives 84 – 87 , respectively. Moreover, sulfurization and selenation of pyridone 75 with sulfur and selenium in the presence of triethylamine afforded the fused pyridine 88 and 89 , respectively (Scheme ) .…”

“…Pyridine is a basic heterocyclic organic compound incorporated into the structure of many pharmaceuticals. Among these, substituted cyanopyridines (nicotinonitriles) were found to have antihypertensive , anti‐inflammatory, analgesic, and antipyretic properties ; antimicrobial, cardiotonic, and anticancer activities ; and 1KK‐b inhibitor properties .…”

Some Products from C=O Condensations of Quinacridones

“…Method B: The QA 1b (1.0 g, 1.9mmol) and the dioxopyridine [15] (1 g, 4.5 mmol) were reacted and worked up in the usual way. The organic phase was separated, the solvent removed by evaporation, and the residue was simmered with methanol (25 mL) for 5 min and cooled.…”