Synthesis and Antibacterial Screening of 1-(2-(2-Chlorophenyl)-2-(4-(6-Fluorobenzo[d]isoxazol-3-Yl)piperidin-1-Yl) Containing 1,3,4-Thiadiazole, 1,2,4-Triazole and 1,3,4-Oxadiazole Derivatives

Abstract

A series of novel 1,3,4-thiadiazole, 1,2,4-triazole and 1,3,4-oxadiazole have been synthesized from 1-(2-(2-chlorophenyl)-2-(4-(6fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)acetyl)-4-phenyl thiosemicarbazide 6 and their antimicrobial activities were reported. Compounds 6b, 6c, 9a, 9b, 9d and 9e have shown moderate activity towards Bacillus Subtilis and Escherichia Coli bacterial species. The structure of synthesized compounds was confirmed by spectral analysis.