Synthesis and Antibacterial Screening of 1,3,4‐Thiadiazoles, 1,2,4‐Triazoles, and 1,3,4‐Oxadiazoles Containing Piperazine Nucleus

Abstract

A series of novel 1,3,4‐thiadiazoles, 1,2,4‐triazoles, and 1,3,4‐oxadiazoles were synthesized by cyclization of substituted 1‐(2‐(2‐chlorophenyl)‐2‐(4‐(2,3‐dichlorophenyl)piperazin‐1‐yl)acetyl)thiosemicarbazide. The structures of all newly synthesized compounds were elucidated on the basis of spectral studies. Some of them were screened for their antibacterial activity. The compounds 6b, 6c, 8e, 9a, and 9b have shown moderate activity towards Bacillus Subtilis and Escherichia Coli.

Synthesis and Characterization of Novel 1‐Methyl‐3‐(4‐phenyl‐4H‐1,2,4‐triazol‐3‐yl)‐1H‐indazole Derivatives

“…Preparation of 2‐(1‐methyl‐1 H ‐indazole‐3‐carbonyl)‐ N ‐phenylhydrazine‐1‐carbothioamides 3a – f was carried out by the reaction of 1‐methyl‐1 H ‐indazole‐3‐carbohydrazide 1 with substituted phenyl isothiocyanates 2a – f in isopropyl alcohol . The IR spectrum of compound 3a showed characteristics bands at 3246, 3197, and 3169 cm −1 (N─H), 1673 cm −1 (C═O), and 1202 cm −1 (C═S).…”

“…Moreover, indazole‐containing compounds showed their potential as selective 5‐HT4 receptor antagonists and inhibitors of glycogen synthase kinase 3β . 1,2,4‐Triazole derivatives show broad spectrum of pharmacological activities including antibacterial , antifungal , anticonvulsant , anti‐inflammatory , antitumor , anticancer , and antiviral .…”

New S- And N- Substituted Derivatives Of 5-Aryloxymethyl-1,2,4-Triazoles And Their Biological Activity

“…A pronounced antibacterial activity is exhibited by many polysubstituted 1,2,4-triazoles, which combine various pharmacologically active groups in their structure [3,4]. It has been established that the introduction of halogen-containing aryl-and aryloxymethyl substituents into various positions of the heterocycle ring significantly increases the activity or expands the spectrum of the biological action of the compound [5,6].…”